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Sulbutiamine Stats & Data

Stimulant Supplement

Sulbut Enerion Arcalion Youvitan Bisibuthiamine

PubChem CID 3002120

NPS DataHub

MW702.9

FormulaC32H46N8O6S2

CAS3286-46-2

IUPAC[(Z)-4-[(4-amino-2-methylpyrimidin-5-yl)methyl-formylamino]-3-[[(Z)-2-[(4-amino-2-methylpyrimidin-5-yl)methyl-formylamino]-5-(2-methylpropanoyloxy)pent-2-en-3-yl]disulfanyl]pent-3-enyl] 2-methylpropanoate

SMILESO=CN(Cc1cnc(C)nc1N)C(C)=C(CCOC(=O)C(C)C)SSC(CCOC(=O)C(C)C)=C(C)N(C=O)Cc1cnc(C)nc1N

InChIKeyCKHJPWQVLKHBIH-ZDSKVHJSSA-N

Chemical Class Thiamine disulfide

Psychoactive Class Stimulant

Pharmacology

DrugBank

Description

Sulbutiamine is a synthetic derivative of thiamine (vitamin B1) under the market name Arcalion that is composed of two modified thiamine molecules to form a dimer. It is highly lipophilic, allowing it to cross the blood-brain barrier more easily than other thiamine derivatives. Although its clinical efficacy is not yet defined, sulbutiamine is used to treat asthenia. While its other uses include improvement of erectile dysfunction and reduction of psycho-behavioural inhibition, sulbutiamine showed evidence of modulatory effect on dopaminergic and glutamatergic cortical transmissions. The chronic administration of the drug has demonstrated to improve long term memory formation in mice.

Effect Profile

Curated

Stimulant 3.8

Moderate stimulation and euphoria with strong anxiety/jitters

Stimulation / Energy×3

Euphoria / Mood Lift×2

Focus / Productivity×2

Anxiety / Jitters×1

Based on reports from:

Erowid Experience Reports

Tolerance & Pharmacokinetics

drugs.wiki

Tolerance Decay

Full tolerance 1d Half tolerance 10d Baseline ~18d

Experience Report Analysis

Erowid

2 Reports

0 Single-substance

2009–2020 Date Range

2 With Age Data

Demographics

Gender Distribution

Too few reports for a chart: gender is known from 2 reports, and a split is drawn only from 20 reports or more. Counts are shown instead. Why 20?