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    Quazepam molecular structure

    Quazepam Stats & Data

    Depressant Benzodiazepine
    Doral
    PubChem CID 4999
    NPS DataHub
    MW386.8
    FormulaC17H11ClF4N2S
    CAS36735-22-5
    IUPAC7-chloro-5-(2-fluorophenyl)-1-(2,2,2-trifluoroethyl)-3H-1,4-benzodiazepine-2-thione
    SMILESFC(F)(F)CN1C(=S)CN=C(c2ccccc2F)c2cc(Cl)ccc12
    InChIKeyIKMPWMZBZSAONZ-UHFFFAOYSA-N
    Chemical Class 1,4-Benzodiazepine
    Psychoactive Class Depressant

    Pharmacology

    DrugBank
    Half-life 39 hours State Solid Metabolism Hepatic.

    Description

    Quazepam is a drug which is a benzodiazepine derivative. It induces impairment of motor function and has hypnotic properties. Quazepam is used to treat insomnia.

    Pharmacodynamics

    Quazepam is a benzodiazepine derivative. The main pharmacological action of quazepam is the enhancement of the neurotransmitter GABA at the GABAA receptor.

    Absorption

    Bioavailability is 29-35% following oral administration.

    Indication

    Used to treat insomnia.

    Toxicity

    PubChem

    Benzodiazepines bind nonspecifically to benzodiazepine receptors, which affects muscle relaxation, anticonvulsant activity, motor coordination, and memory. As benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABA<sub>A</sub>) receptors, this enhances the effects of GABA by increasing GABA affinity for the GABA receptor.

    Carcinogenicity

    No indication of carcinogenicity to humans (not listed by IARC).

    Liver injury risk

    No documented concern

    FDA LiverTox / DILIrank. Reflects published case reports of liver injury, not absolute risk.

    Health effects (PubChem excerpts)

    They cause slurred speech, disorientation and "drunken" behavior. They are physically and psychologically addictive.

    Tolerance & Pharmacokinetics

    drugs.wiki

    No tolerance chart. Our decay curves for these drugs were estimates, and a curve can make tolerance look longer-lasting than it is, which is the dangerous direction.

    How fast tolerance to these drugs fades after a break has not been measured well enough to draw, so don't count on a dose you used to take still being safe: after time off, start with a much smaller amount and don't use alone. Mixing sedatives with each other, with alcohol or with opioids sharply raises the risk of a fatal overdose. If you've been using regularly, don't stop suddenly: withdrawal from benzodiazepines, alcohol or GHB/GBL can cause seizures or delirium, so get medical help to cut down gradually.

    Sources: FRANK: benzodiazepines · Alcohol and Drug Foundation: GHB · FDA 2020: benzodiazepine boxed warning · FDA 2019: gabapentinoids and breathing · NHS: alcohol use disorder

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