Proscaline Stats & Data

Proscaline was first synthesized and investigated by Czech chemist Otakar Leminger in 1972. The compound was subsequently synthesized by David E. Nichols, who published his work in the Journal of Medicinal Chemistry in 1977. Around this period, Alexander Shulgin independently explored the substance, evaluating its effects at doses up to 60 milligrams and estimating its potency to be approximately five times greater than that of mescaline. Shulgin later documented his findings on proscaline in his 1991 book PiHKAL (Phenethylamines I Have Known and Loved), which served as the primary reference for the compound's subjective effects for many years. Despite this early documentation, proscaline remained largely obscure until it appeared for sale on the online research chemical market during the 2010s. The substance was first identified as a novel designer drug in Europe in 2013.

The toxicity and long-term health effects of recreational proscaline use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. Anecdotal evidence from people who have tried proscaline within the psychedelic community suggests that there are no negative health effects attributed to trying this drug, but nothing can be completely guaranteed. It is strongly recommended that one use harm reduction practices when using this drug.

Effects aggregated from 5 experience reports (5 single-substance Erowid)

Each bar is the share of reports mentioning the effect; its whisker, and the band on the rows below, is the 95% interval: where the share could plausibly be with other reports of the same kind.

Too few reports for bars: these effects come from 5 single-substance Erowid reports, and a bar is drawn only from 20 reports or more. With fewer, a percentage cannot tell a common effect from a rare one. Counts are shown instead. Why 20?

From 9 of 11 recorded dose entries: those that state a weight (mg, g or µg), in routes with at least five of them. Values above Q3 + 3×IQR, far above what people typically take, are left out; they can include real heavy doses and overdoses, not only mistakes.

Most common forms and preparations, as a share of the 4 reports that give one

Too few reports for bars: these forms come from 4 reports, and a bar is drawn only from 20 reports or more. With fewer, a percentage cannot tell a common effect from a rare one. Counts are shown instead. Why 20?

• Capsule 2 of 4
• Powder / Crystals 2 of 4