Well, to begin, I am very experienced with opiates and opioids. I started my love affair with opiates after a series of accidents and surgeries where Percocet was prescribed after every occasion. From there I was enthralled by that opiate high and pursued any opiate/opiod I could find.
Oxymorphone
Well-documented
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 4 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 29 combo interactions documented
- toxicity data (PsychonautWiki, PubChem)
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 4 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 29 combo interactions documented
- toxicity data (PsychonautWiki, PubChem)
Aliases: Opana, Numorphan, Stop signs, stopsigns
Summary
Oxymorphone (also known by the brand name Opana) is a semi-synthetic opioid analgesic used in the management of moderate to severe pain, and is similar in structure to other opioids such as morphine and heroin. Oxymorphone was first developed in Germany in 1914and introduced to the American market in 1959. Unlike many other opioids, oxymorphone is almost devoid of antitussive properties.Oxymorphone is an important precursor to other opioids and opioid antagonists such as naloxone.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral | 5-10mg | 10-20mg | 20-30mg | 30mg+ |
| Insufflated | 2-4mg | 4-8mg | 8-15mg | 15mg+ |
Light
Common
Strong
Heavy
Sources· 1 of 2 ladders not identified
Oral
Dose ladder — dose.wiki, PsychonautWikiInsufflated
Dose ladder — source not identifiedOnset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 20-45 min | 30-60 min | 1-2 hrs | 2-4 hrs | 3.83-7.75 hrs |
| Insufflated | 5-10 min | 15-30 min | 1-2 hrs | 1-3 hrs | 2.33-5.67 hrs |
| Rectal | 10-30 min | 30-60 min | 1.5-3 hrs | 2-3 hrs | 4.17-7.5 hrs |
Opioid MME Calculator
⚠ Citation & Disclaimer:
Conversion factors sourced from the
NIH HEAL Initiative MME Calculator (Adams et al., PAIN 2025),
the CDC 2022 Clinical Practice Guideline for Prescribing Opioids for Pain,
and the MDCalc MME Calculator.
These are approximate equianalgesic ratios for educational reference only.
Individual responses vary significantly based on genetics, tolerance, cross-tolerance, and route of administration.
This is not medical advice. Do not use these conversions to adjust opioid dosing without professional medical guidance.
mg
3.3
mg
Oxymorphone
≈
—
mg
Morphine
| Substance | Equivalent Dose | MME Factor |
|---|
⚠ Equianalgesic dose ratios are approximations and do not account for genetic factors, tolerance, incomplete cross-tolerance, or pharmacokinetic variations. Methadone conversion is especially variable at higher doses. Always consult a healthcare provider before making any changes to opioid therapy.
Effect Profile
66 reportsScores (0–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Validated against 56 Erowid trip reports
- Weighted by importance: core (×3), major (×2), minor (×1)
Opioid
8.0
Intense
8/10
Strong euphoria and pain relief with strong itching/nausea, moderate sedation
Euphoria / Warmth
×3
10
physical euphoria
cognitive euphoria
euphoria
mood lift
Analgesia
×2
10
pain relief
analgesia
Sedation / Relaxation
×1
6
sedation
dream potentiation
Itching / Nausea
×1
10
nausea
constipation
dry mouth
Based on reports from:
Tolerance
Build-up
develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
Reset
Falls quickly once you stop, at a rate you can't judge. After any break, treat your tolerance as gone.
No tolerance chart. Our decay curves for opioids were estimates, and a curve can make tolerance look longer-lasting than it is, which is the dangerous direction.
Opioid tolerance drops fast when you stop, and even a few days off can be enough, so a dose that used to be normal can now stop your breathing. Overdose deaths rise sharply after prison, detox or leaving treatment, and tolerance also falls during a hospital stay. After any break, start with a much smaller amount, try a test dose first, don't use alone, and keep naloxone within reach. Alcohol, benzodiazepines, gabapentinoids and other sedatives make an opioid overdose much more likely.
Sources: FRANK: heroin · National Harm Reduction Coalition · WHO: opioid overdose · Merrall et al. 2010 · Binswanger et al. 2007 · Strang et al. 2003 · FDA 2019: gabapentinoids and breathing
Effects
Aggregated from 56 single-substance Erowid and 10 Bluelight experience reports; 15 Erowid reports where another drug was taken too are left out
Each bar shows the share of analyzed reports whose text mentions that effect — a mention is not always a first-hand experience (fear of an effect or something witnessed can count). Mentions saying the effect did not happen are left out; that check reads keywords, so it can miss some. The shaded band on a bar, and the small range after its number, is the 95% interval: where the share could plausibly be with other reports of the same kind. Fewer reports, wider band. Tap or hover any number for details. The second value is the Bluelight extractor's per-effect confidence; a dash means the row is Erowid-derived, which has no confidence measurement.
Rows resting on fewer than 20 reports show a count (“3 of 7”) instead of a bar. Why 20?
Effect glossary — · full glossary
Positive Effects 14
54.6% (95% interval 43 to 66 percent)
91%
28.8% (95% interval 19 to 41 percent)
65%
25.8% (95% interval 17 to 37 percent)
86%
16.7% (95% interval 10 to 27 percent)
75%
13.6% (95% interval 7 to 24 percent)
90%
10.6% (95% interval 5 to 20 percent)
83%
7.5% (95% interval 3 to 16 percent)
80%
2 of 10
85%
2 of 10
85%
1 of 10
85%
1 of 10
70%
1 of 10
80%
1 of 10
90%
1 of 10
80%
Adverse Effects 15
39.4% (95% interval 28 to 52 percent)
80%
16.7% (95% interval 10 to 27 percent)
85%
14.3% (95% interval 7 to 26 percent)
–
7.6% (95% interval 3 to 16 percent)
85%
4 of 10
80%
3 of 10
80%
2 of 10
82%
2 of 10
95%
1 of 10
75%
1 of 10
80%
1 of 10
75%
1 of 10
70%
1 of 10
80%
1 of 10
75%
1 of 10
90%
Also reported in combinations. In the 15 Oxymorphone reports where another drug was taken too, 6 mention hospital, emergency services or an overdose, 0 a seizure and 0 psychosis (too few reports for percentages). In the 56 single-substance reports: 33.9%, 1.8% and 0.0%. These are not in the figures above: they cannot be put down to Oxymorphone alone, and a mention is not always something that happened to the writer.
Combinations
Cross-Check Oxymorphone with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, Bluelight, and Dose.wiki. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.
Erowid 8 reports 4 positive 1 neutral 3 cautionary visit
As an avid fan of most of the schedule II opiates and opioids, I am no stranger to the cycle of use, which is quite similar among all the substances in these classes. First time use is a little confusing as you try to pinpoint and analyze the effects, not really knowing what everyone else is talking about.
I had my first encounter with Oxymorphone in November 2009 when I snorted 5mg with my friend Zach, who was moving some to make extra cash. It was like no other opiate I had ever experienced, and I loved every second of it, from the breathtaking rush to the warm and euphoric nod.
Well let me begin by stating that my experience with drugs is one that a veteran might only know of. I have tried everything excluding heroine, and meth. Many of things I have tried just because my attitude since I was 15 has been one of always wanting to push the limits and know what these great chemicals do to my own...
I noticed a lack of reports for Oxymorphone (In particular, Opana) and because this is one of the greatest gifts that God (Or Buddha, Allah, or whoever else you believe exists) could have given us, I felt I had to give something to go on! Now, I consider myself a very experienced user of all opiates, and especially oxy...
Last year I had surgery on a very tender spot. I struggled an unusual amount of time afterward with the pain, much longer than normal postoperative care. Eventually I ended up seeing a pain management specialist because the medications the surgeon was prescribing weren't helping much (mostly percocet, but after I had b...
I had been looking for some 10mg lortabs for a few months. I looked in all the usual places, and even through people because I needed some so bad. No one had any, but one guy did have a 30mg Opana. But it would cost me around $30. Now, if I'm going to spend more than $20, I would like it to last me a while.
Just to show where my tolerance level was by the time this night had come about. I would say that I have an extremely high tolerance compared to most. This all started at age 15 with the basic Tylenol w/ codeine pills.
Bluelight 7 threads 3 neutral 4 cautionary visit
I had been a regular oxycontin user for several months prior to runnin' up on some Opana. The opportunity struck me randomly one day, and I jumped on the opportunity to try some of this fabled oxymorphone junk.
Alright, Opana ER 40mg. before this, i have only done hydrocodone, oxycodone, and codeine (ignoring synthetics). I have a fair deal of experience with those three, but my use is very recreational and i have never had a tolerance or even a once a week habit. they are not a regular thing in my life.
I picked up some opana ER 20's the other day, 7 of them to be exact. now, i've never been one to bitch about prices but i paid $XX each for these and was expecting great things to come. i've never paid more than $X/mg but i figured there was something special about oxymorphone. anyway...
I thought I would give some 1st hand account details regarding my experience with Opana IR 10mg. A little background: I have been taking opiates for about 4 years. I have chronic pain from 2 injuries. I was taken off of 10mg Norco once I developed a tolerance and it was no longer providing pain relief.
Hi guys I'm really new to bluelight so please just bear with me if I'm violating guidelines just lmk because I still don't know all the rules yet. This is a "trip" report about my friends op expierence.
Warning: Dosages in this report are not recommended. The dosage is, in fact, reckless. Respect your body. Don't be a fool. First and foremost this mixture was highly leathal, and would never suggest anyone too go this off the books. T0:00 - 7am, At the time I'm a senior in high school.
Hello all, I'd like to start off by saying I'm 16, male, 5'9, 153lbs. It all began about a month ago, my friend's mom had prescribes to Opanas (40mg with a little bit of yellow coating), I kinda put it in the back of my head because I'm more of a Tripping guy NOT a Nodding guy.
Pill Identifiers
9
known pill identifiers on record — view imprints, colors, shapes, and images
→
Oxymorphone's nerd page
Pharmacology, chemical data, effect profiles, and more
→
Helpful Links
Add missing routes to PsychonautWiki Journal
The PsychonautWiki Journal app already has Oxymorphone, but its built-in entry only covers Oral. Here are the other routes we have data for. You can't edit a built-in substance, but you can add a Custom Unit for any of these routes to log it.
⬇ Download import file
Import this file as custom substances
and you get "Oxymorphone (Substance Search)" with every
route's full dose ladder and timeline, no typing. Works on iOS and
Android (v15+); the format is confirmed by the app's
developer. The manual values below work for older
versions.
Custom Unit doses
- Insufflatedcommon ~ 6 mg
Dose & duration (reference)
Oxymorphone: routes the PsychonautWiki Journal app is missing Source: SubstanceSearch (substancesearch.com) Insufflated dose (mg): light 2-4 · common 4-8 · strong 8-15 · heavy 15+ Insufflated duration: onset 5-10m · come-up 15-30m · peak 1-2h · offset 1-3h · total 2.33-5.67h · after-effects 6h Rectal duration: onset 10-30m · come-up 0.5-1h · peak 1.5-3h · offset 2-3h · total 4.17-7.5h · after-effects 6h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Custom Units carry a single dose per route, so the full ranges live in the reference above. A route's suggested dose is the midpoint of its common range. Ranges are harm-reduction guidance, not a prescription.
Report an issue or suggest an edit
Spotted incorrect or dangerous information, have a correction, a new study, or a useful addition for Oxymorphone? Let us know. Reports are reviewed by moderators — this is not posted publicly.