Normethadone Stats & Data
NPS DataHub
MW295.42
FormulaC20H25NO
CAS467-85-6
IUPAC6-dimethylamino-4,4-diphenyl-hexan-3-one
SMILES
CCC(=O)C(CCN(C)C)(c1ccccc1)c1ccccc1InChIKey
WCJFBSYALHQBSK-UHFFFAOYSA-N
Chemical Class
Diphenylpropylamine
Pharmacology
DrugBank
State Solid
Description
Normethadone is used as an opioid antitussive in combination with DB11610. It is marketed in Canada by Valeant under the tradename Cophylac.
Mechanism of Action
Normethadone activates central opioid receptors in the medulla to supress the cough reflex . It also likely activates peripheral opioid receptors to inhibit signalling by irritant receptors of the airway.
Pharmacodynamics
Normethadone is an opioid which suppresses coughing by central and peripheral mechanisms .
Indication
For use in the treatment of cough when other less potent treatments have failed .
Toxicity
DrugBankToxicity (DrugBank)
The toxic effects of normethadone are similar to those of other opioids. It can produce respiratory depression, depression of central nervous system function, and constipation .