Nitemazepam Stats & Data
O=N(=O)c1ccc2N(C)C(=O)C(O)N=C(c3ccccc3)c2c1.[H+]QRWVNMAJJIQCEG-UHFFFAOYSA-OHistory & Culture
Nitemazepam, also known as 3-hydroxynimetazepam, is a benzodiazepine derivative that was originally synthesized during the 1970s. Despite its early development, the compound was never brought to market as a pharmaceutical product. Decades after its initial synthesis, nitemazepam resurfaced as a designer drug within the research chemical market. The substance was first definitively identified in Europe in 2017, representing part of a broader trend of novel benzodiazepines entering grey market circulation.
Effect Profile
CuratedStrong euphoria with low anxiolysis, sedation, and cognitive impairment
Tolerance & Pharmacokinetics
drugs.wikiNo tolerance chart. Our decay curves for these drugs were estimates, and a curve can make tolerance look longer-lasting than it is, which is the dangerous direction.
How fast tolerance to these drugs fades after a break has not been measured well enough to draw, so don't count on a dose you used to take still being safe: after time off, start with a much smaller amount and don't use alone. Mixing sedatives with each other, with alcohol or with opioids sharply raises the risk of a fatal overdose. If you've been using regularly, don't stop suddenly: withdrawal from benzodiazepines, alcohol or GHB/GBL can cause seizures or delirium, so get medical help to cut down gradually.
Sources: FRANK: benzodiazepines · Alcohol and Drug Foundation: GHB · FDA 2020: benzodiazepine boxed warning · FDA 2019: gabapentinoids and breathing · NHS: alcohol use disorder