Let me start off by saying that while this is a fantastic drug, I believe the possibilities for abuse are extremely high. My experience started off like any other day, my friend (N) told me that he got his hands on some morphine and wanted to know if I'd split 100mg with him.
Morphine
Well-documented
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 4 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 29 combo interactions documented
- toxicity data (PsychonautWiki, PubChem)
Well-documented
Multiple authoritative sources agree on dosing and effects.
- 4 corroborating sources
- 2 ROAs with full dose ladders
- duration data present
- 29 combo interactions documented
- toxicity data (PsychonautWiki, PubChem)
Aliases: M, Morpho, Monkey, Dreamer, Roxanol
Summary
Morphine is a potent naturally-occurring opioid analgesic extracted from the opium poppy, used for moderate to severe pain management. Overdose can result in fatal respiratory depression, especially when combined with other CNS depressants. Long-acting formulations exist for extended pain relief.
Dose Information
| ROA | Light | Common | Strong | Heavy |
|---|---|---|---|---|
| Oral BA 35%-40% | 5-10mg | 10-20mg | 20-30mg | 30mg+ |
| Intravenous BA ~100% | 3.33-5mg | 5-7.5mg | 7.5-10mg | 10mg+ |
Onset, Duration & After-effects
| ROA | Onset | Comeup | Peak | Offset | Total |
|---|---|---|---|---|---|
| Oral | 10-30 min | 20-40 min | 2-3 hrs | 1-2 hrs | 4-6 hrs |
| Intravenous | 0-36 sec | 2-5 min | 1.5-2.5 hrs | 60-90 min | 2.53-4.09 hrs |
| Intramuscular | 10-30 min | 20-40 min | 1-2 hrs | 2-4 hrs | 3.5-7.17 hrs |
Opioid MME Calculator
⚠ Citation & Disclaimer:
Conversion factors sourced from the
NIH HEAL Initiative MME Calculator (Adams et al., PAIN 2025),
the CDC 2022 Clinical Practice Guideline for Prescribing Opioids for Pain,
and the MDCalc MME Calculator.
These are approximate equianalgesic ratios for educational reference only.
Individual responses vary significantly based on genetics, tolerance, cross-tolerance, and route of administration.
This is not medical advice. Do not use these conversions to adjust opioid dosing without professional medical guidance.
mg
10
mg
Morphine
≈
—
mg
Morphine
| Substance | Equivalent Dose | MME Factor |
|---|
⚠ Equianalgesic dose ratios are approximations and do not account for genetic factors, tolerance, incomplete cross-tolerance, or pharmacokinetic variations. Methadone conversion is especially variable at higher doses. Always consult a healthcare provider before making any changes to opioid therapy.
Effect Profile
88 reportsScores (0–10) curated from multiple sources:
- Effect keyword matching from PsychonautWiki catalog
- Validated against 78 Erowid trip reports
- Weighted by importance: core (×3), major (×2), minor (×1)
Opioid
6.9
Strong+
7/10
Strong pain relief with strong itching/nausea, moderate euphoria and sedation
Euphoria / Warmth
×3
7
physical euphoria
cognitive euphoria
euphoria
mood lift
“Preparing your shot in a warm environment may assist as well as things like wearing a warm hat (beanie etc) and jumpers, tracksuits.”
“The guide on here says use 10 to 20 mls of warm water.”
Analgesia
×2
9
pain relief
analgesia
“– Morphine is a highly potent opiate analgesic psychoactive drug, is the principal active ingredient in Papaver somniferum (opium), is considered to be the prototypical opioid.”
Sedation / Relaxation
×1
7
sedation
muscle relaxation
dream potentiation
“and i usually plug all of it except 30mgs, which i put up my nose*(even though the B/A isnt great), it just seems like having the powder in my nose satisfies the urgent need to get high and then a...”
Itching / Nausea
×1
8
nausea
constipation
dry mouth
“Withdrawals are like most other drugs of this class; nausea, tearing, yawning, chills, body aches, insomnia, loss of appetite, dysphoria and excessive sweating, etc lasting anywhere up to a week or...”
“What could be done to prevent a strong nausea/stomach cramping from taking a 30mg generic MS Contin as prescribed?”
User Experience
pain relief
“– Morphine is a highly potent opiate analgesic psychoactive drug, is the principal active ingredient in Papaver somniferum (opium), is considered to be the prototypical opioid.”
Based on reports from:
Tolerance
Build-up
develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
Reset
Falls quickly once you stop, at a rate you can't judge. After any break, treat your tolerance as gone.
No tolerance chart. Our decay curves for opioids were estimates, and a curve can make tolerance look longer-lasting than it is, which is the dangerous direction.
Opioid tolerance drops fast when you stop, and even a few days off can be enough, so a dose that used to be normal can now stop your breathing. Overdose deaths rise sharply after prison, detox or leaving treatment, and tolerance also falls during a hospital stay. After any break, start with a much smaller amount, try a test dose first, don't use alone, and keep naloxone within reach. Alcohol, benzodiazepines, gabapentinoids and other sedatives make an opioid overdose much more likely.
Sources: FRANK: heroin · National Harm Reduction Coalition · WHO: opioid overdose · Merrall et al. 2010 · Binswanger et al. 2007 · Strang et al. 2003 · FDA 2019: gabapentinoids and breathing
Cross-Tolerances
Effects
Aggregated from 78 single-substance Erowid and 10 Bluelight experience reports; 59 Erowid reports where another drug was taken too are left out
Each bar shows the share of analyzed reports whose text mentions that effect — a mention is not always a first-hand experience (fear of an effect or something witnessed can count). Mentions saying the effect did not happen are left out; that check reads keywords, so it can miss some. The shaded band on a bar, and the small range after its number, is the 95% interval: where the share could plausibly be with other reports of the same kind. Fewer reports, wider band. Tap or hover any number for details. The second value is the Bluelight extractor's per-effect confidence; a dash means the row is Erowid-derived, which has no confidence measurement.
Rows resting on fewer than 20 reports show a count (“3 of 7”) instead of a bar. Why 20?
Effect glossary — · full glossary
Positive Effects 28
40.9% (95% interval 31 to 51 percent)
91%
29.6% (95% interval 21 to 40 percent)
85%
19.3% (95% interval 12 to 29 percent)
90%
16.7% (95% interval 10 to 26 percent)
–
12.8% (95% interval 7 to 22 percent)
–
10.3% (95% interval 5 to 19 percent)
–
9.1% (95% interval 5 to 17 percent)
85%
8.0% (95% interval 4 to 16 percent)
80%
8.0% (95% interval 4 to 16 percent)
85%
6.8% (95% interval 3 to 14 percent)
90%
6.4% (95% interval 3 to 14 percent)
–
5 of 10
82%
3 of 10
88%
2 of 10
85%
2 of 10
92%
2 of 10
75%
1 of 10
85%
1 of 10
90%
1 of 10
85%
1 of 10
80%
Show 8 more positive effects
1 of 10
80%
1 of 10
90%
1 of 10
85%
1 of 10
80%
1 of 10
85%
1 of 10
80%
1 of 10
80%
1 of 10
85%
Adverse Effects 19
28.4% (95% interval 20 to 39 percent)
85%
19.3% (95% interval 12 to 29 percent)
85%
12.8% (95% interval 7 to 22 percent)
–
Auditory Effects
9.1% (95% interval 5 to 17 percent)
90%
6.4% (95% interval 3 to 14 percent)
–
5.1% (95% interval 2 to 12 percent)
–
3.8% (95% interval 1 to 11 percent)
–
3.8% (95% interval 1 to 11 percent)
–
2 of 10
82%
1 of 10
95%
1 of 10
90%
1 of 10
90%
1 of 10
85%
1 of 10
90%
1 of 10
85%
1 of 10
80%
1 of 10
85%
1 of 10
90%
1 of 10
80%
Also reported in combinations. In the 59 Morphine reports where another drug was taken too, 13 (22.0%) mention hospital, emergency services or an overdose, 1 (1.7%) a seizure and 0 (0.0%) psychosis. In the 78 single-substance reports: 23.1%, 0.0% and 1.3%. These are not in the figures above: they cannot be put down to Morphine alone, and a mention is not always something that happened to the writer.
Combinations
Cross-Check Morphine with another substanceCommunity Trip Reports
Anecdotal first-person accounts from Reddit, Erowid, Bluelight, and Dose.wiki. Click a source to expand. Reports are harm-reduction context, not medical guidance. Tags summarise each author's own verdict — how reports are classified.
Erowid 8 reports 2 positive 1 neutral 5 cautionary visit
The first time I had morphine was when I went to the emergency room for kidney stones. I was throwing up everywhere, in massive pain, and they gave me an IV injection of morphine.
intravenous morphine I have shot up some morphine intranvenously a couple of times. The morphine was MD surplus, and it's quite easy for me to obtain sterile needles and syringes.
I should start off by saying that Im a very experienced opiate user. Ive used almost every prescription painkiller under the sun, though as of late theyve been hard to come by. I also smoke pot a few times a week and have used stimulants like Adderall on and off over the years.
A Very Powerful Experience Some background information: I come from a relatively well-situated standard familiar background in Europe. I had the luck to study materials science at a very reputated university in Europe and graduated last year.
I have read very little first-hand accounts of IV use of oral preparations of Morphine Sulfate. Partially, I think it is due to the scarcity of 30mL vials of Oral Morphine. I figured I would write my experience to add to the knowledge of others. Personal Info: 32 year old white male, 6ft, 155lbs.
Working in a veterinary hospital and having friends that work at people hospitals allows for some interesting experiences. There are times when unusual medications come our way, and without causing harm to others (we don't steal medicine from patients) we can experiment with different classes of drugs.
[Erowid Note: Because opiate use can lead to significant tolerance (requiring higher doses for the same effects), the dose used by a first time user is significantly smaller than that used by a regular user. It can be extremely dangerous to choose ones dose on the basis of the amount taken by someone else.
Bluelight 6 threads 1 positive 5 neutral visit
Experience includes: Vicodin, Codeine and Percocet I am 140 lbs, male and have not experienced Opiates in well over 6 months so I have zero tolerance at this point in time. My four friends all decided the superbowl would be an excellent occasion to trip due to the fact that we had no parental supervision.
So, about 2 weeks ago I got my hands on 2 30 mg Actavis Sustained Release Morphine pills from a friend of mine. Now keep in mind I have no opioid/opiate tolerance(I did 15 mg Lortab approximately 1 week before this.), so at the time I didn't realize that taking 60 mg of morphine was kind of a higher starting dose for s...
EDIT: Sorry about the title, didn't read the guidelines in time. Just last night I discovered in the depths of my parent's med cabinet a bottle of 10mg/5ml liquid morphine sulfate, which once upon a time belonged to my grandfather who sadly passed six months ago.
Good evening BLerz! Trip report numero uno for me! Huzzah! I did a favour for a friend and in return scored myself a hefty stash of 50mg Kapanol capsules. Decided to IV one, so here's my recollection Me- I've been a drug user for 10 years now, I'm addicted to speed and IV approximately 4-5grams a week, dependant on fun...
Previous opioid use: Codeine, propoxyphene, and hydrocodone, both alone and in combinations of all 3 that contained up to the equivalent of ~150mg codeine + sometimes pseudoephedrine and amantadine(which had been in the same bag and I assumed it was an opioid).
So I've done my share of opiates, I don't do them a lot or enough to have a tolerance, but I've tried a lot and I've experienced morphine on one other occassion besides this. Some was had and this is what transpired.
Pill Identifiers
7
known pill identifiers on record — view imprints, colors, shapes, and images
→
Morphine's nerd page
Pharmacology, chemical data, effect profiles, and more
→
Helpful Links
Add missing routes to PsychonautWiki Journal
The PsychonautWiki Journal app already has Morphine, but its built-in entry only covers Intravenous, Oral. Here are the other routes we have data for. You can't edit a built-in substance, but you can add a Custom Unit for any of these routes to log it.
⬇ Download import file
Import this file as custom substances
and you get "Morphine (Substance Search)" with every
route's full dose ladder and timeline, no typing. Works on iOS and
Android (v15+); the format is confirmed by the app's
developer. The manual values below work for older
versions.
Duration (reference)
Morphine: routes the PsychonautWiki Journal app is missing Source: SubstanceSearch (substancesearch.com) Intramuscular duration: onset 10-30m · come-up 20-40m · peak 1-2h · offset 2-4h · total 3.5-7.17h · after-effects 6-12h Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.
Ranges are harm-reduction guidance, not a prescription.
Report an issue or suggest an edit
Spotted incorrect or dangerous information, have a correction, a new study, or a useful addition for Morphine? Let us know. Reports are reviewed by moderators — this is not posted publicly.