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    ⚠ Benzodiazepines can cause physical dependence with regular use. Withdrawal can be life-threatening. Never combine with opioids or alcohol.

    Mexazolam Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 1 source
    • 1 ROA with full dose ladder
    • duration data present
    • 27 combo interactions documented
    • PubChem toxicity data

    Aliases: Melex, Sedoxil

    Summary TripSit

    Benzodiazepine derivative that has been trialed for anxiety and was found to be effective for anxiety at one week week follow-ups yet after three weeks it had lost its therapeutic anxiolytic properties and becoming no more effective than placebo.

    Dose Information source varies by band

    ROA Light Common Strong Heavy
    Oral 0.25-0.5mg 0.5-1.5mg 1.5-2mg 2-3mg+
    Light Common Strong Heavy
    Sources· 1 of 1 ladders not fully identified

    Oral

    Dose ladder — Light–Strong: dose.wiki, TripSit · Heavy: not identified

    Onset, Duration & After-effects TripSit

    ROA Onset Peak After Effects Total
    Oral 5-45 min 4-8 hrs 1-12 hrs 4-8 hrs

    Tolerance

    Build-up develops over 1–4 weeks of daily use; hypnotic tolerance faster than anxiolytic tolerance
    Reset Falls after you stop, at a rate that varies from person to person. If you've been using regularly, cut down gradually with medical help rather than stopping suddenly.

    No tolerance chart. Our decay curves for these drugs were estimates, and a curve can make tolerance look longer-lasting than it is, which is the dangerous direction.

    How fast tolerance to these drugs fades after a break has not been measured well enough to draw, so don't count on a dose you used to take still being safe: after time off, start with a much smaller amount and don't use alone. Mixing sedatives with each other, with alcohol or with opioids sharply raises the risk of a fatal overdose. If you've been using regularly, don't stop suddenly: withdrawal from benzodiazepines, alcohol or GHB/GBL can cause seizures or delirium, so get medical help to cut down gradually.

    Sources: FRANK: benzodiazepines · Alcohol and Drug Foundation: GHB · FDA 2020: benzodiazepine boxed warning · FDA 2019: gabapentinoids and breathing · NHS: alcohol use disorder

    Combinations TripSit

    Cross-Check Mexazolam with another substance

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    Helpful Links

    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track Mexazolam there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "Mexazolam (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    Mexazolam
    Unit
    mg
    Description
    Mexazolam
    Source: SubstanceSearch (substancesearch.com)
    
    Oral dose (mg): light 0.25-0.5 · common 0.5-1.5 · strong 1.5-2 · heavy 2-3+
    
    Oral duration: onset 5-45m · peak 4-8h · total 4-8h · after-effects 1-12h
    
    Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 1 mg (Oral).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.