Mexamine Stats & Data
JTEJPPKMYBDEMY-UHFFFAOYSA-NPharmacology
DrugBankMetabolism
5-methoxytryptamine has known human metabolites that include serotonin.
Measured Affinities
Guide to PHARMACOLOGYMeasured binding and functional data for 5-MeOT, curated by the IUPHAR/BPS Guide to PHARMACOLOGY. Each row cites the paper it came from. Lower concentrations mean tighter binding — a value in the sub-nanomolar range indicates a very potent interaction.
| Target | Action | Measure | Value | Concentration | Species | Source |
|---|---|---|---|---|---|---|
| 5-HT2A receptor HTR2A | Full agonist | pKi | 8.9 | 1.26 nM | Human | PMID 8114677 |
| 5-HT7 receptor Htr7 | Full agonist | pKi | 8.2 | 6.31 nM | Mouse | PMID 8394987 |
| 5-HT2A receptor Htr2a | Full agonist | pKi | 8.1 | 7.94 nM | Rat | PMID 8114677 |
| 5-HT2B receptor Htr2b | Full agonist | pKi | 8 | 10 nM | Rat | PMID 8450835 |
| 5-HT6 receptor HTR6 | Full agonist | pKi | 7.4 | 39.81 nM | Human | PMID 8522988 |
| 5-HT4 receptor Htr4 | Full agonist | pKi | 6.6 | 251.19 nM | Mouse | PMID 8946946 |
| 5-HT2C receptor Htr2c | Full agonist | pKi | 6.3 | 501.19 nM | Rat | PMID 9282936 |
| 5-HT1F receptor HTR1F | Full agonist | pKi | 5.9 | 1,259 nM | Human | PMID 8380639 |
| 5-HT1B receptor HTR1B | Full agonist | pKi | — | — | Human | — |
| 5-HT1D receptor HTR1D | Full agonist | pKi | — | — | Human | — |
| 5-HT2C receptor HTR2C | Full agonist | pKi | — | — | Human | PMID 10611640 |
| 5-HT4 receptor Htr4 | Full agonist | pKi | — | — | Rat | — |
| 5-HT4 receptor HTR4 | Full agonist | pKi | — | — | Human | — |
| 5-HT6 receptor Htr6 | Full agonist | pKi | — | — | Rat | — |
| 5-HT7 receptor HTR7 | Full agonist | pKi | — | — | Human | — |
| 5-HT7 receptor Htr7 | Full agonist | pKi | — | — | Rat | — |
| 5-ht1e receptor HTR1E | Full agonist | pKi | — | — | Human | — |
Reading this. pKi, pEC50 and pIC50 are negative log molar values, so a higher number means a tighter interaction; the concentration column converts them for you. Values from non-human species are laboratory measurements and do not translate directly to human effect. Receptor affinity is not a dose — it describes what a molecule binds, not how much of it is safe to take.
Receptor data from the IUPHAR/BPS Guide to PHARMACOLOGY (v2026.2), licensed CC BY-SA 4.0. Matched to this substance by InChIKey.
Effect Profile
CuratedMild visuals with low body load and headspace