- Analysis enhancement
- Anxiety
- Appetite suppression
- Cognitive euphoria
- Cognitive fatigue
- Dehydration
- Depression
- Focus enhancement
- Increased heart rate
- Increased perspiration
- Irritability
- Memory enhancement
- Motivation enhancement
- Stimulation
- Teeth grinding
- Thought acceleration
- Thought deceleration
- Thought organization
- Wakefulness
Methylphenidate
Aliases: mph, ritalin, concerta, biphentin
Categories
Summary
A psychostimulant commonly used in the treatment of ADHD, narcolepsy and obesity, particularly in the EU instead of Adderall. Methylphenidate is also a 5HT1A receptor agonist. Sometimes prescribed off-label to help the withdrawals from cocaine and other stimulants.
Dose Information
Onset, Duration & After-effects
- Onset:
- Insufflated_IR: 5-10 minutes
- Insufflated_XR: 5-10 minutes
- Oral_ER: 30-120 minutes
- Oral_IR: 30-120 minutes
- Duration:
- Insufflated: 2-4 hours
- Oral_ER: 8-12 hours
- Oral_IR: 3-6 hours
- After-effects: 1-24 hours
Effects
- Increased alertness
- Euphoria
- Increased motivation
- Reduced appetite
- Flushing of the face
- Increased body temperature
- Tachycardia (Increased heart rate)
- Paranoia
- Insomnia
Studies
- A chemical ionization selected ion monitoring assay for methylphenidate and ritalinic acid
- Panlobular pulmonary emphysema caused by i.v. injection of methylphenidate (Ritalin): findings on chest radiographs and CT scans.
- Ethylphenidate formation in human subjects after the administration of a single dose of methylphenidate and ethanol.
- A comparison of methylphenidate-, amphetamine-, and methamphetamine-induced hyperthermia and neurotoxicity in male Sprague-Dawley rats during...
- Methylphenidate and brain dopamine neurotoxicity.
- Methylphenidate treatment induces oxidative stress in young rat brain.
- A comprehensive in vitro screening of d-, l-, and dl-threo-methylphenidate: an exploratory study.
- Methylphenidate and its ethanol transesterification metabolite ethylphenidate: brain disposition, monoamine transporters and motor activity.
- The psychostimulant d-threo-(R,R)-methylphenidate binds as an agonist to the 5HT(1A) receptor.
- Methylphenidate combined with aripiprazole in children and adolescents with bipolar disorder and attention-deficit/hyperactivity disorder
- Isopropylphenidate: an ester homolog of methylphenidate with sustained and selective dopaminergic activity and reduced drug interaction
- Object memory impairment at post-drug Day 15 but not at Day 1 after a regimen of repeated treatment with oral methylphenidate.
- Long Withdrawal of Methylphenidate Induces a Differential Response of the Dopaminergic System and Increases Sensitivity to Cocaine in the Prefrontal Cortex of Spontaneously Hypertensive Rats.
- A chemical ionization selected ion monitoring assay for methylphenidate and ritalinic acid.
- A comparison of methylphenidate-, amphetamine-, and methamphetamine-induced hyperthermia and neurotoxicity in male Sprague-Dawley rats during the w...
- Methylphenidate and brain dopamine neurotoxicity.
- Methylphenidate combined with aripiprazole in children and adolescents with bipolar disorder and attention-deficit/hyperactivity disorder: a random...
- Long Withdrawal of Methylphenidate Induces a Differential Response of the Dopaminergic System and Increases Sensitivity to Cocaine in the Prefronta...
- IV use of methylphenidate can lead to infections and abscesses due to the fillers in the medication
- Pregnancy category C according to the FDA