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    Disclaimer
    ☠ This is an extremely potent opioid active in microgram doses. Accidental overdose can be rapidly fatal. Naloxone should always be on hand.
    🧪 This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    Methoxyacetyl-Fentanyl Encyclopedic
    Encyclopedic
    Typical encyclopedia coverage. Cross-reference for important decisions.
    • 2 corroborating sources
    • 1 ROA with full dose ladder
    • 29 combo interactions documented
    • classified Research-chemical

    Aliases: MAF, Desfluoroocfentanil

    Depressant Research-chemical Opioid

    Summary TripSit

    A quite potent fentanyl analogue.

    Dose Information dose.wiki TripSit

    Dose basis. TripSit is the only source for these figures and states three tiers ending in an open "Strong: 1.5 mg and above" — there is no Heavy band and no established ceiling. The numbers are compiled from user reports rather than measured, on a fentanyl analogue where the difference between tiers is a fraction of a milligram.

    ROA Light Common Strong
    Oral 0.25-0.5mg 0.5-1.5mg 1.5mg+
    Light Common Strong
    Sources

    Oral

    Dose ladder — dose.wiki, TripSit

    Tolerance

    Build-up develops within days of regular use; analgesic tolerance faster than respiratory depression tolerance
    Reset Falls quickly once you stop, at a rate you can't judge. After any break, treat your tolerance as gone.

    No tolerance chart. Our decay curves for opioids were estimates, and a curve can make tolerance look longer-lasting than it is, which is the dangerous direction.

    Opioid tolerance drops fast when you stop, and even a few days off can be enough, so a dose that used to be normal can now stop your breathing. Overdose deaths rise sharply after prison, detox or leaving treatment, and tolerance also falls during a hospital stay. After any break, start with a much smaller amount, try a test dose first, don't use alone, and keep naloxone within reach. Alcohol, benzodiazepines, gabapentinoids and other sedatives make an opioid overdose much more likely.

    Sources: FRANK: heroin · National Harm Reduction Coalition · WHO: opioid overdose · Merrall et al. 2010 · Binswanger et al. 2007 · Strang et al. 2003 · FDA 2019: gabapentinoids and breathing

    Combinations TripSit

    Cross-Check Methoxyacetyl-Fentanyl with another substance

    Helpful Links

    📖 TripSit
    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track Methoxyacetyl-Fentanyl there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    Name
    Methoxyacetyl-Fentanyl
    Unit
    mg
    Description 
    Methoxyacetyl-Fentanyl
Source: SubstanceSearch (substancesearch.com)

Oral dose (mg): light 0.25-0.5 · common 0.5-1.5 · strong 1.5+

Oral duration: after-effects 1-4h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 1 mg (Oral).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.