Isomethadone Stats & Data
CCC(=O)C(C(C)CN(C)C)(c1ccccc1)c1ccccc1IFKPLJWIEQBPGG-UHFFFAOYSA-NHistory & Culture
Isomethadone, also known by the alternative name isoamidone, is a synthetic opioid analgesic structurally related to methadone. It was previously marketed as a pharmaceutical product under the trade name Liden, where it saw clinical use for both pain management and cough suppression. The compound has since been withdrawn from the pharmaceutical market and is no longer commercially available as a medication.
Effect Profile
CuratedModerate euphoria with mild pain relief and itching/nausea, low sedation
Tolerance & Pharmacokinetics
drugs.wikiNo tolerance chart. Our decay curves for opioids were estimates, and a curve can make tolerance look longer-lasting than it is, which is the dangerous direction.
Opioid tolerance drops fast when you stop, and even a few days off can be enough, so a dose that used to be normal can now stop your breathing. Overdose deaths rise sharply after prison, detox or leaving treatment, and tolerance also falls during a hospital stay. After any break, start with a much smaller amount, try a test dose first, don't use alone, and keep naloxone within reach. Alcohol, benzodiazepines, gabapentinoids and other sedatives make an opioid overdose much more likely.
Sources: FRANK: heroin · National Harm Reduction Coalition · WHO: opioid overdose · Merrall et al. 2010 · Binswanger et al. 2007 · Strang et al. 2003 · FDA 2019: gabapentinoids and breathing