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Imodium Stats & Data

Depressant Opioid

Fad Lope Select Entrocalm Immodium a-d

PubChem CID 71420

PubChem

MW513.5

FormulaC29H34Cl2N2O2

IUPAC4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide;hydrochloride

InChIKeyPGYPOBZJRVSMDS-UHFFFAOYSA-N

Chemical Class Phenylpiperidine

Psychoactive Class Depressant

Measured Affinities

Guide to PHARMACOLOGY

Measured binding and functional data for loperamide, curated by the IUPHAR/BPS Guide to PHARMACOLOGY. Each row cites the paper it came from. Lower concentrations mean tighter binding — a value in the sub-nanomolar range indicates a very potent interaction.

Target	Action	Measure	Value	Concentration	Species	Source
μ receptor OPRM1	Agonist	pKi	9.28	0.525 nM	Human	PMID 15454210

Reading this. pKi, pEC50 and pIC50 are negative log molar values, so a higher number means a tighter interaction; the concentration column converts them for you. Values from non-human species are laboratory measurements and do not translate directly to human effect. Receptor affinity is not a dose — it describes what a molecule binds, not how much of it is safe to take.

Receptor data from the IUPHAR/BPS Guide to PHARMACOLOGY (v2026.2), licensed CC BY-SA 4.0. Matched to this substance by InChIKey.

Toxicity

PubChem

Liver injury risk

No documented concern

FDA LiverTox / DILIrank. Reflects published case reports of liver injury, not absolute risk.

Effect Profile

Curated

Opioid 6.0

Strong euphoria with moderate itching/nausea, mild pain relief, low sedation

Euphoria / Warmth×3

Analgesia×2

Sedation / Relaxation×1

Itching / Nausea×1

Based on reports from:

Erowid Experience Reports PsychonautWiki Imodium

Tolerance & Pharmacokinetics

drugs.wiki

Tolerance Decay

Full tolerance 1d Half tolerance 21d Baseline ~35d

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