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    Flutoprazepam molecular structure

    Flutoprazepam Stats & Data

    Restas Kb-509
    NPS DataHub
    MW342.8
    FormulaC19H16ClFN2O
    CAS25967-29-7
    IUPAC7-chloro-1-(cyclopropylmethyl)-5-(2-fluorophenyl)-3H-1,4-benzodiazepin-2-one
    SMILESClc1ccc2N(CC3CC3)C(=O)CN=C(c3ccccc3F)c2c1
    InChIKeyOFVXPDXXVSGEPX-UHFFFAOYSA-N
    Benzodiazepines
    Chemical Class 1,4-Benzodiazepine
    Psychoactive Class Depressant

    Receptor Profile

    Receptor Actions

    Modulators
    GABA-A receptor positive allosteric modulator (benzodiazepine site)

    Effect Profile

    Curated
    Benzodiazepine 7.4

    Strong anxiolysis and euphoria with strong cognitive impairment, mild sedation

    Anxiolysis×3
    10
    Sedation / Relaxation×2
    5
    Motor / Cognitive Impairment×1
    8
    Euphoria / Mood Lift×1
    10
    Based on reports from:

    Tolerance & Pharmacokinetics

    drugs.wiki
    Half-Life
    Estimated 60–90 h for parent; active metabolite norflurazepam commonly reported 50–120 h, contributing to very prolonged effects.
    Addiction Potential
    High; like other benzodiazepines, flutoprazepam carries substantial risks of tolerance, dependence, and a potentially dangerous withdrawal syndrome after sustained or heavy use.

    No tolerance chart. Our decay curves for these drugs were estimates, and a curve can make tolerance look longer-lasting than it is, which is the dangerous direction.

    How fast tolerance to these drugs fades after a break has not been measured well enough to draw, so don't count on a dose you used to take still being safe: after time off, start with a much smaller amount and don't use alone. Mixing sedatives with each other, with alcohol or with opioids sharply raises the risk of a fatal overdose. If you've been using regularly, don't stop suddenly: withdrawal from benzodiazepines, alcohol or GHB/GBL can cause seizures or delirium, so get medical help to cut down gradually.

    Sources: FRANK: benzodiazepines · Alcohol and Drug Foundation: GHB · FDA 2020: benzodiazepine boxed warning · FDA 2019: gabapentinoids and breathing · NHS: alcohol use disorder

    Cross-Tolerances

    Other benzodiazepines
    Z-drugs
    Barbiturates

    Experience Report Analysis

    Erowid
    1 Reports
    0 Single-substance
    2017–2017 Date Range
    1 With Age Data

    Demographics

    Gender Distribution

    Too few reports for a chart: gender is known from 1 report, and a split is drawn only from 20 reports or more. Counts are shown instead. Why 20?

    • Female 1 of 1

    Age Distribution

    Reports Over Time

    Benzodiazepine Equivalence

    2.5 mg Flutoprazepam = 10.0 mg Diazepam
    Potency ratio 4.0

    Flutoprazepam - ~2.5mg ~=10mg Diazepam.

    ⚠ All other CNS depressants.

    Harm Reduction

    drugs.wiki

    Flutoprazepam is a long-acting benzodiazepine; its primary active metabolite is norflurazepam (a.k.a. desalkylflurazepam), which has a long half-life and contributes to prolonged sedation and accumulation. This greatly increases next-day impairment and the risk that redosing will lead to blackouts. Driving or operating machinery can remain unsafe for 24–48+ hours after dosing, particularly with repeated use. Combining flutoprazepam with opioids, alcohol, GHB/GBL, or other depressants markedly raises overdose risk through additive/synergistic respiratory and CNS depression; naloxone will reverse opioid effects but not benzodiazepine sedation, so mixed overdoses may only be partially reversed. Long-acting benzodiazepines commonly appear in drug checking of the unregulated opioid supply (e.g., benzo-dope), which complicates overdose response and recovery; test your supply when possible and assume sedation may outlast the opioid. Tolerance to benzodiazepines can develop within days to weeks of regular use, while reversal of tolerance can take weeks; avoid daily use and space sessions by multiple days to reduce escalation. Abrupt cessation after frequent use can precipitate a dangerous withdrawal (including seizures); if dependent, taper gradually with medical supervision rather than stopping suddenly. Elderly individuals and those with pulmonary disease or sleep apnea are at increased risk of falls, confusion, and respiratory depression with long-acting benzodiazepines. Avoid using stimulants to counter sedation: this does not restore coordination/judgment and increases the likelihood of risky redosing. Because active duration is very long, single-dose trials should be small and well-spaced (e.g., at least 72 hours) before considering any redose. If using powders or liquids of uncertain strength, employ volumetric dosing to improve accuracy; in an unregulated market, consider drug checking services to verify identity and dose.

    References

    Data Sources

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