Flutoprazepam Stats & Data
Clc1ccc2N(CC3CC3)C(=O)CN=C(c3ccccc3F)c2c1OFVXPDXXVSGEPX-UHFFFAOYSA-NReceptor Profile
Receptor Actions
Effect Profile
CuratedStrong anxiolysis and euphoria with strong cognitive impairment, mild sedation
Tolerance & Pharmacokinetics
drugs.wikiNo tolerance chart. Our decay curves for these drugs were estimates, and a curve can make tolerance look longer-lasting than it is, which is the dangerous direction.
How fast tolerance to these drugs fades after a break has not been measured well enough to draw, so don't count on a dose you used to take still being safe: after time off, start with a much smaller amount and don't use alone. Mixing sedatives with each other, with alcohol or with opioids sharply raises the risk of a fatal overdose. If you've been using regularly, don't stop suddenly: withdrawal from benzodiazepines, alcohol or GHB/GBL can cause seizures or delirium, so get medical help to cut down gradually.
Sources: FRANK: benzodiazepines · Alcohol and Drug Foundation: GHB · FDA 2020: benzodiazepine boxed warning · FDA 2019: gabapentinoids and breathing · NHS: alcohol use disorder
Cross-Tolerances
Experience Report Analysis
ErowidDemographics
Gender Distribution
Too few reports for a chart: gender is known from 1 report, and a split is drawn only from 20 reports or more. Counts are shown instead. Why 20?
- Female 1 of 1
Age Distribution
Reports Over Time
Benzodiazepine Equivalence
Flutoprazepam - ~2.5mg ~=10mg Diazepam.
Harm Reduction
drugs.wikiFlutoprazepam is a long-acting benzodiazepine; its primary active metabolite is norflurazepam (a.k.a. desalkylflurazepam), which has a long half-life and contributes to prolonged sedation and accumulation. This greatly increases next-day impairment and the risk that redosing will lead to blackouts. Driving or operating machinery can remain unsafe for 24–48+ hours after dosing, particularly with repeated use. Combining flutoprazepam with opioids, alcohol, GHB/GBL, or other depressants markedly raises overdose risk through additive/synergistic respiratory and CNS depression; naloxone will reverse opioid effects but not benzodiazepine sedation, so mixed overdoses may only be partially reversed. Long-acting benzodiazepines commonly appear in drug checking of the unregulated opioid supply (e.g., benzo-dope), which complicates overdose response and recovery; test your supply when possible and assume sedation may outlast the opioid. Tolerance to benzodiazepines can develop within days to weeks of regular use, while reversal of tolerance can take weeks; avoid daily use and space sessions by multiple days to reduce escalation. Abrupt cessation after frequent use can precipitate a dangerous withdrawal (including seizures); if dependent, taper gradually with medical supervision rather than stopping suddenly. Elderly individuals and those with pulmonary disease or sleep apnea are at increased risk of falls, confusion, and respiratory depression with long-acting benzodiazepines. Avoid using stimulants to counter sedation: this does not restore coordination/judgment and increases the likelihood of risky redosing. Because active duration is very long, single-dose trials should be small and well-spaced (e.g., at least 72 hours) before considering any redose. If using powders or liquids of uncertain strength, employ volumetric dosing to improve accuracy; in an unregulated market, consider drug checking services to verify identity and dose.
References
Data Sources
Cited References
- Barzaghi et al. 1989: Pharmacokinetics of flutoprazepam
- Bluelight: Flutoprazepam Discussion Thread
- DrugBank: Flutoprazepam
- Erowid Experience: Restas Regret
- PsychonautWiki: Benzodiazepines
- PsychonautWiki: Dangerous Combinations
- ScienceDirect: Flutoprazepam Overview
- Sukamoto et al. 1980: Psychopharmacological studies of KB-509
- TripSit Factsheet: Flutoprazepam
- TripSit Wiki: Benzodiazepines
- TripSit Wiki: Drug Combinations
- TripSit Wiki: Uncommon Benzodiazepines
- Bluelight: Flutoprazepam or Restas
- TripSit Factsheet: Norflurazepam
- TripSit Wiki: Benzodiazepines
- Drug-Do: Benzos
Additional references
- Bluelight — Benzo discussion table listing flutoprazepam (Restas) dosing and 60–90 h duration
- Bluelight thread: Flutoprazepam/Restas (Japan-exclusive) user reports
- EUDA/EMCDDA drug profile: Benzodiazepines (class effects, durations, harms, overdose risks)
- Isomer Design: Norflurazepam synonyms include N‑desalkylflutoprazepam (metabolite link)
- PubChem: Desalkylflurazepam (Norflurazepam) CID 4540
- TripSit combinations: depressant mixing (alcohol/benzos) flagged dangerous
- DrugChecking.community (Toronto Drug Checking Service): frequent benzodiazepine co-detection with opioids; naloxone limits when benzos present
- NCBI Bookshelf: Concurrent benzo–opioid use linked to increased overdose risk (systematic evidence)
- NCBI CBHSQ/DAWN: ED outcomes worse with benzos plus alcohol/opioids
- Hi-Ground benzodiazepine harm-reduction page (unsafe combos; dependence/withdrawal warnings)