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    Etorphine molecular structure

    Etorphine Stats & Data

    Opioid
    PubChem CID 644209
    NPS DataHub
    MW411.54
    FormulaC25H33NO4
    CAS14521-96-1
    IUPAC(1~{R},2~{S},6~{R},14~{R},15~{R},19~{R})-19-[(2~{R})-2-hydroxypentan-2-yl]-15-methoxy-5-methyl-13-oxa-5-azahexacyclo[13.2.2.1^{2,8}.0^{1,6}.0^{2,14}.0^{12,20}]icosa-8(20),9,11,16-tetraen-11-ol(1~{R},2~{S},6~{R})-19-(2-hydroxypentan-2-yl)-15-methoxy-5-methyl-13-oxa-5-azahexacyclo[13.2.2.1^{2,8}.0^{1,6}.0^{2,14}.0^{12,20}]icosa-8(20),9,11,16-tetraen-11-ol(1~{R},2~{S},6~{R},14~{R},15~{R},19~{R})-19-[(2~{S})-2-hydroxypentan-2-yl]-15-methoxy-5-methyl-13-oxa-5-azahexacyclo[13.2.2.1^{2,8}.0^{1,6}.0^{2,14}.0^{12,20}]icosa-8(20),9,11,16-tetraen-11-ol(1~{R},2~{S},6~{S},14~{R},15~{R},19~{R})-19-(2-hydroxypentan-2-yl)-15-methoxy-5-methyl-13-oxa-5-azahexacyclo[13.2.2.1^{2,8}.0^{1,6}.0^{2,14}.0^{12,20}]icosa-8(20),9,11,16-tetraen-11-ol(1~{S},2~{S},6~{R},14~{R},15~{S},19~{R})-19-[(2~{R})-2-hydroxypentan-2-yl]-15-methoxy-5-methyl-13-oxa-5-azahexacyclo[13.2.2.1^{2,8}.0^{1,6}.0^{2,14}.0^{12,20}]icosa-8(20),9,11,16-tetraen-11-ol
    SMILESCCCC(C)(O)C1CC23C=CC1(OC)C1Oc4c(O)ccc5CC3N(C)CCC12c45
    InChIKeyCAHCBJPUTCKATP-FAWZKKEFSA-N
    Chemical Class Oripavine

    Pharmacology

    DrugBank
    State Solid

    Description

    A narcotic analgesic morphinan used as a sedative in veterinary practice. In certain countries, etorphine is classified as a Schedule 1 drug and hence, in these countries, it can be used legally only by health professionals and for research purposes. Etorphine is only available to the patients under an official prescription. In the US, Etorphine is listed as a Schedule I drug, although Etorphine hydrochloride is classified as Schedule II.

    Mechanism of Action

    Etorphine is an agonist at mu, delta, and kappa opioid receptors. It also has a weak affinity for the ORL1 nociceptin/orphanin FQ receptor.

    Pharmacodynamics

    Etorphine is a synthetic cousin of morphine and 40,000 times more powerful.

    Indication

    Etorphine is only available for its use in veterinary. This main usage is related to the immobilization of large mammals.

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