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    DMT molecular structure

    DMT Stats & Data

    Dmitry Dimitri N,n-dmt Fantasia The glory dimethyltryptamine
    PubChem
    MW188.27
    FormulaC12H16N2
    LogP2.5
    IUPAC2-(1H-indol-3-yl)-N,N-dimethylethanamine
    SMILESCN(C)CCC1=CNC2=CC=CC=C21
    InChIKeyDMULVCHRPCFFGV-UHFFFAOYSA-N
    Chemical Class Substituted tryptamine
    Psychoactive Class Psychedelic

    Pharmacology

    DrugBank
    State Solid

    Description

    An N-methylated indoleamine derivative, a serotonergic hallucinogen found in several plants, especially Prestonia amazonica (Apocynaceae) and in mammalian brain, blood, and urine. It apparently acts as an agonist at some types of serotonin receptors and an antagonist at others.

    Mechanism of Action

    DMT acts as a non-selective agonist at most or all of the serotonin receptors.

    Indication

    Some people use this compound as a psychedelic inducing agent.

    Receptor Profile

    Receptor Actions

    Agonists
    5-HT2A receptor agonist (partial)
    5-HT1A receptor agonist (partial)
    5-HT2C receptor agonist (partial)
    Sigma-1 receptor agonist

    Measured Affinities

    Guide to PHARMACOLOGY

    Measured binding and functional data for dimethyltryptamine, curated by the IUPHAR/BPS Guide to PHARMACOLOGY. Each row cites the paper it came from. Lower concentrations mean tighter binding — a value in the sub-nanomolar range indicates a very potent interaction.

    Target Action Measure Value Concentration Species Source
    5-HT6 receptor HTR6 Full agonist pKi 7.2 63.1 nM Human PMID 8522988
    5-HT1D receptor HTR1D Full agonist pKi — — Human PMID 8967979

    Reading this. pKi, pEC50 and pIC50 are negative log molar values, so a higher number means a tighter interaction; the concentration column converts them for you. Values from non-human species are laboratory measurements and do not translate directly to human effect. Receptor affinity is not a dose — it describes what a molecule binds, not how much of it is safe to take.

    Receptor data from the IUPHAR/BPS Guide to PHARMACOLOGY (v2026.2), licensed CC BY-SA 4.0. Matched to this substance by InChIKey.

    History & Culture

    DMT has been used as an entheogen in South America for thousands of years, primarily in the form of ayahuasca brews and snuffs. Archaeological evidence suggests snuff use dating back several millennia, though DMT typically served as a minor constituent in these preparations rather than the primary compound. Amazonian tribes have traditionally employed ayahuasca to receive guidance from protective spirits, gain insight into the causes and treatments of illness, perceive future events, communicate with distant groups, prepare for warfare and hunting, and identify enemies and their intentions.

    1931–1957

    DMT was first synthesized in 1931 by Richard Helmuth Fredrick Manske, a Canadian chemist. The compound's hallucinogenic properties remained unknown for another quarter century until Hungarian chemist and psychiatrist Stephen Szára investigated them in 1956. Szára had initially attempted to acquire LSD from Sandoz Laboratories in Switzerland, but his request was denied on the grounds that such a potent psychotropic substance could prove dangerous in the hands of a communist country. This rejection led him to synthesize DMT in his own laboratory and test it on himself through injection. He subsequently administered it to several medical colleagues before expanding his study to thirty additional participants, predominantly physicians. In 1955, DMT was definitively isolated from a plant source for the first time, extracted from Anadenanthera peregrina seeds used in traditional snuff preparations. Two years later, American chemists identified DMT in leaves of a plant they erroneously named "Prestonia amazonicum." This taxonomic error later influenced writer William Burroughs, who experimented with DMT in Tangier in 1961 under the belief he was using "Prestonia."

    1930s–1961

    Following the Amazon rubber boom, several syncretic religious movements incorporating ayahuasca emerged in Brazil. These traditions blended indigenous South American practices with Catholic and European influences alongside Brazilian cosmological beliefs. Santo Daime, the first of these movements, was founded in the 1930s by Raimundo Irineu Serra, a Brazilian rubber tapper. Barquinha formed in 1945 through a schism with Santo Daime. The União do Vegetal was established in 1961 by Jose Gabriel da Costa, also a rubber tapper. These religious movements would later become central to legal challenges regarding DMT's controlled status, with the UDV's 2006 U.S. Supreme Court victory establishing important precedent for religious use exemptions.

    1960s–2010

    During the 1960s in the United States, DMT earned the colloquial name "businessman's trip" due to its rapid onset, intense effects, and relatively brief duration—allowing users to experience the full depth of a psychedelic journey in considerably less time than substances like LSD or psilocybin mushrooms. Ethnobotanist Terence McKenna became instrumental in popularizing DMT during the 1980s and 1990s, particularly advocating for inhalation as the preferred route of administration. He spoke enthusiastically and frequently about his experiences, introducing many to the substance's unique phenomenology. In the 1990s, Rick Strassman, a medical doctor at the University of New Mexico Hospital Clinical Research Center, began the first government-approved research on DMT in decades. He selected the compound for study because of its short duration, natural occurrence in humans, potentially unexplored physiological roles, and relative obscurity. His research led to the publication of "DMT: The Spirit Molecule" in 2000 and an accompanying documentary in 2010. Strassman hypothesized that DMT might be produced in the pineal gland and released during dreams, birth, and death—ideas subsequently popularized by McKenna and others, though they remain scientifically unconfirmed.

    A distinctive cultural phenomenon surrounding DMT is the remarkably consistent reports of encounters with apparently autonomous entities during the experience. Terence McKenna coined the term "machine elves" for the beings he first encountered after smoking DMT in Berkeley in 1965, also describing them as "fractal elves" or "self-transforming machine elves." In analyzing self-reports from his clinical study participants, Strassman observed striking similarities between descriptions of these entities and figures from ancient religious traditions, including the Ḥayyot haq-Qodesh from Hebrew mysticism, as well as various depictions of angels and demons. He and others have speculated that such hallucinatory experiences may underlie reports of alien abduction and extraterrestrial encounters, suggesting DMT's effects might illuminate the neurological basis of certain mystical and paranormal experiences.

    Subjective Effects

    Physical
    • Spontaneous tactile sensations: The body high of DMT can be described as a pleasurable, warm, soft, and all encompassing glow. It maintains a consistent presence that quickly rises with the onset and hits its limit once the peak has been reached. It is capable of becoming very powerful at higher doses and remains for up to half an hour after the trip itself.
    • Changes in gravity: At higher dosages physical feelings of being catapulted across vast distances at incredibly high speeds are common.
    Cognitive

    The head space of DMT is described by most as extremely sober and clear headed in its style when compared to other commonly used psychedelics such as LSD, psilocin or even ayahuasca. It contains a limited amount of typical cognitive effects. DMT in its smokeable form is perhaps the least psychologically intoxicating psychedelic, leading many people to describe it not as a drug induced trip but a genuine experience that is actually happening to them.

    • Enhancement of current mind state
    • Removal of cultural filter
    • Feelings of fascination, importance and awe
    • Rejuvenation
    • Direct communication with the subconscious
    • Ego suppression, loss and death
    • States of unity and interconnectedness
    Sensory
    Auditory
    • Enhancements
    • Distortions
    • Hallucinations
    Visual · Distortions
    • Visual drifting: (Melting, Breathing, Morphing and Flowing) - In comparison to other psychedelics, this effect can be described as highly detailed, slow and smooth in motion and static in its appearance.
    • Tracers
    • After images
    • Texture repetition
    • Colour shifting
    • Scenery slicing
    Visual · Enhancements
    • Increased visual acuity
    • Enhancement of colours
    • Enhanced pattern recognition
    Visual · Hallucinatory States

    DMT produces a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of any other commonly used psychedelic.

    • External hallucinations
    • Internal hallucinations: This particular effect commonly contains hallucinations with scenarios, settings, concepts and autonomous entity contact. They are more common within dark environments and can be described as internal in their manifestation, lucid in believability, interactive in style and almost exclusively religious, spiritual, mystical or transcendental in nature.

    Forked from Subjective Effect Documentation by Josie Kins, April 2012. Via dose.wiki (CC0).

    Toxicity

    PsychonautWiki

    DMT is considered to be non-addictive, is not associated with any form of neurotoxicity, and has an extremely low toxicity relative to dose. As with other psychedelic substances, there are relatively few physical side effects associated with acute DMT exposure. Various studies have shown that in reasonable doses in a careful context, it has little to no negative cognitive, psychiatric or physical consequences. However, as with psychedelics generally, DMT is thought to be able to act as a potential trigger for those with underlying psychiatric conditions. Those with a personal or family history of mental illness are advised not to use this substance unless under medical supervision.

    Addiction & dependence

    Like other serotonergic psychedelics, DMT is considered to be non-addictive with a low abuse potential. There are no literature reports of successful attempts to train animals to self-administer DMT — an animal model predictive of abuse liability — indicating that it does not have the necessary pharmacology to either initiate or maintain dependence. Likewise, there is virtually no withdrawal syndrome when chronic use of DMT is stopped.

    Effect Profile

    Curated + 889 Reports
    Psychedelic 9.1

    Strong visuals, headspace, and auditory effects with mild body load

    Visual Intensity×3
    10105.3 6/25
    Headspace Depth×3
    107.73.3 7/25
    Auditory Effects×1
    8102.2 8/25
    Body Load / Somatic Effects×1
    51.71.9 4/25
    Catalog Erowid BlueLight

    User Experiences

    Visuals "I sat up at the edge of the bed and opened my eyes, distortions such as visual drifting along with geometric patterns still covered my whole field of vision." — Effect Index ↗
    Headspace "Complete and utter ego death hits." — Effect Index ↗
    Auditory Effects "At about 90 seconds I started hearing a powerful sound that was not coming from the ears." — Bluelight ↗

    Duration Timeline

    Bluelight
    Onset Comeup Peak Offset After Effects
    Smoked
    0-1 minutes
    3-10 minutes
    15 minutes - 1.0 hours
    Oral
    30-45 minutes
    45 minutes - 1.0 hours
    2-3 hours
    1-2 hours
    4 hours
    Insufflated
    3-4 minutes
    45 minutes - 1.0 hours
    15 minutes - 1.0 hours
    Intravenous
    0 minutes
    0 minutes
    0-6 minutes
    12-18 minutes
    15-60 minutes hours

    Community Effects

    TripSit
    Positive
    visual enhancement euphoria introspection
    Negative
    nausea anxiety tachycardia

    Tolerance & Pharmacokinetics

    drugs.wiki
    Half-Life
    ~5–15 min (IV; ultra-rapid distribution/elimination); effects resolve within ~20 min when smoked/vaporized.
    Addiction Potential
    Very low; no documented physical dependence and limited evidence of compulsive use in observational and community data.

    Tolerance Decay

    Full tolerance 0.5h Half tolerance 7d Baseline ~14d

    Human studies found minimal to no rapid psychological tolerance after closely spaced IV administrations compared to other psychedelics; subjective effects remained robust, although some biological measures declined across repeated doses. Community reports suggest the ability to redose within a session with little tolerance, but cumulative physiological/psychological load increases. Data quality is mixed; cross-tolerance with other 5‑HT2A psychedelics is presumed but not well quantified.

    Cross-Tolerances

    psilocybin
    LSD
    mescaline

    Experience Report Analysis

    Erowid BlueLight
    1,043 Reports
    640 Single-substance
    1991–2025 Date Range
    729 With Age Data
    31 Effects Detected

    Demographics

    Gender Distribution

    Age Distribution

    Reports Over Time

    Effect Analysis

    Erowid + Bluelight

    Effects aggregated from 690 experience reports (640 single-substance Erowid + 249 Bluelight)

    690 Reports
    136 Effects Detected
    74 Positive
    31 Adverse
    31 Neutral

    Effect Sentiment Distribution

    Confidence Distribution

    Each bar is the share of reports mentioning the effect; its whisker, and the band on the rows below, is the 95% interval: where the share could plausibly be with other reports of the same kind.

    Positive Effects 74

    Visual Distortions 68.5% (95% interval 65 to 72 percent) 85%
    Entity Imagery 68.0% (95% interval 54 to 79 percent) 90%
    Color Enhancement 61.2% (95% interval 58 to 65 percent) 87%
    Awe 42.0% (95% interval 29 to 56 percent) 86%
    Geometric Imagery 40.0% (95% interval 28 to 54 percent) 88%
    Insight 38.0% (95% interval 26 to 52 percent) 83%
    Empathy 37.4% (95% interval 34 to 41 percent) 80%
    Closed-Eye Visuals 35.2% (95% interval 32 to 39 percent) 91%
    Euphoria 33.4% (95% interval 30 to 37 percent) 88%
    Stimulation 32.2% (95% interval 29 to 36 percent) 83%
    Music Enhancement 27.2% (95% interval 24 to 31 percent) 86%
    Revelatory Insight 24.0% (95% interval 14 to 37 percent) 86%
    Mystical Quality 24.0% (95% interval 14 to 37 percent) 89%
    Fractal Imagery 24.0% (95% interval 14 to 37 percent) 92%
    Morphing 20.0% (95% interval 11 to 33 percent) 87%
    Wonder 18.0% (95% interval 10 to 31 percent) 84%
    Peace 18.0% (95% interval 10 to 31 percent) 86%
    Introspection 17.4% (95% interval 15 to 20 percent) 83%
    Body High 16.7% (95% interval 14 to 20 percent) 85%
    Environmental Transfiguration 16.0% (95% interval 8 to 28 percent) 88%

    Adverse Effects 31

    Anxiety 54.4% (95% interval 51 to 58 percent) 84%
    Fear 36.0% (95% interval 24 to 50 percent) 84%
    Confusion 26.2% (95% interval 23 to 30 percent) 82%
    Body Load 24.0% (95% interval 14 to 37 percent) 77%
    Depersonalization 24.0% (95% interval 14 to 37 percent) 80%
    Panic 14.0% (95% interval 7 to 26 percent) 86%
    Memory Suppression 9.8% (95% interval 8 to 12 percent) 82%
    Pressure 8.0% (95% interval 3 to 19 percent) 82%
    Sweating 8.0% (95% interval 3 to 19 percent) 85%
    Nausea 6.2% (95% interval 5 to 8 percent) 76%
    Thought Disorganization 6.0% (95% interval 2 to 16 percent) 80%
    Increased Heart Rate 5.3% (95% interval 4 to 7 percent) 70%
    Taste Distortion 4.0% (95% interval 1 to 14 percent) 88%
    Vomiting 4.0% (95% interval 1 to 14 percent) 88%
    Dread 4.0% (95% interval 1 to 14 percent) 95%
    Motor Impairment 3.8% (95% interval 3 to 6 percent) 80%
    ⚠ Psychosis 2.7% (95% interval 2 to 4 percent) 70%
    Muscle Tension 2.7% (95% interval 2 to 4 percent) 70%
    Thought Loops 2.6% (95% interval 2 to 4 percent) 78%
    Jaw Clenching 2.2% (95% interval 1 to 4 percent) 70%
    ⚠ Seizure 0.8% (95% interval 0 to 2 percent) 70%
    Show 10 more adverse effects
    Pupil Dilation 2.2% (95% interval 1 to 4 percent) 70%
    Loneliness 2.0% (95% interval 0 to 10 percent) 75%
    Muscle Spasm 2.0% (95% interval 0 to 10 percent) 75%
    Social Anxiety 2.0% (95% interval 0 to 10 percent) 90%
    Contrast Enhancement 2.0% (95% interval 0 to 10 percent) 70%
    Temporal Disorientation 2.0% (95% interval 0 to 10 percent) 80%
    Tremor 2.0% (95% interval 0 to 10 percent) 75%
    Headache 2.0% (95% interval 0 to 10 percent) 75%
    Paranoia 2.0% (95% interval 0 to 10 percent) 80%
    Vulnerability 2.0% (95% interval 0 to 10 percent) 80%
    Show 31 neutral or unclassified mentions
    Auditory Effects 26.1% (95% interval 23 to 30 percent)
    Dissociation 22.5% (95% interval 20 to 26 percent)
    Time Dilation 22.0% (95% interval 13 to 35 percent)
    Thought Acceleration 20.0% (95% interval 11 to 33 percent)
    Time Distortion 12.9% (95% interval 11 to 16 percent)
    Ego Dissolution 12.4% (95% interval 10 to 15 percent)
    Body Distortion 8.0% (95% interval 3 to 19 percent)
    Pareidolia 6.0% (95% interval 2 to 16 percent)
    Focus Suppression 6.0% (95% interval 2 to 16 percent)
    Sedation 4.6% (95% interval 3 to 6 percent)
    Hospital 4.2% (95% interval 3 to 6 percent)
    Crying 4.0% (95% interval 1 to 14 percent)
    Mandala Imagery 4.0% (95% interval 1 to 14 percent)
    Communication Suppression 2.0% (95% interval 0 to 10 percent)
    Body Vibration 2.0% (95% interval 0 to 10 percent)
    Pitch Shifting 2.0% (95% interval 0 to 10 percent)
    Heaviness 2.0% (95% interval 0 to 10 percent)
    Depth Distortion 2.0% (95% interval 0 to 10 percent)
    Size Distortion 2.0% (95% interval 0 to 10 percent)
    Appetite Suppression 2.0% (95% interval 0 to 10 percent)
    Cold Sweat 2.0% (95% interval 0 to 10 percent)
    External Auditory Hallucination 2.0% (95% interval 0 to 10 percent)
    Lightheadedness 2.0% (95% interval 0 to 10 percent)
    Meta-Awareness Of Irrationality 2.0% (95% interval 0 to 10 percent)
    Numbness 2.0% (95% interval 0 to 10 percent)
    Auditory Suppression 2.0% (95% interval 0 to 10 percent)
    Salivation 2.0% (95% interval 0 to 10 percent)
    Field Narrowing 2.0% (95% interval 0 to 10 percent)
    Auditory Echo 2.0% (95% interval 0 to 10 percent)
    Motor Automatisms 2.0% (95% interval 0 to 10 percent)
    Acceptance 2.0% (95% interval 0 to 10 percent)

    Also reported in combinations. In the 403 DMT reports where another drug was taken too, 19 (4.7%) mention hospital, emergency services or an overdose, 5 (1.2%) a seizure and 15 (3.7%) psychosis. In the 640 single-substance reports: 4.2%, 0.8% and 2.7%. These are not in the figures above: they cannot be put down to DMT alone, and a mention is not always something that happened to the writer.

    Dose-Response Correlation

    How effect frequency changes across dose levels. Whiskers, and the numbers' hover text, give each figure's 95% interval.

    View data table
    Effect Common (n=29) Strong (n=38) Heavy (n=36)
    Visual Distortions 69.0% (95% interval 51 to 83 percent) 89.5% (95% interval 76 to 96 percent) 77.8% (95% interval 62 to 88 percent)
    Color Enhancement 62.1% (95% interval 44 to 77 percent) 71.1% (95% interval 55 to 83 percent) 72.2% (95% interval 56 to 84 percent)
    Anxiety 62.1% (95% interval 44 to 77 percent) 55.3% (95% interval 40 to 70 percent) 47.2% (95% interval 32 to 63 percent)
    Closed-Eye Visuals 48.3% (95% interval 31 to 66 percent) 47.4% (95% interval 32 to 63 percent) 36.1% (95% interval 22 to 52 percent)
    Empathy 34.5% (95% interval 20 to 53 percent) 44.7% (95% interval 30 to 60 percent) 44.4% (95% interval 30 to 60 percent)
    Euphoria 20.7% (95% interval 10 to 38 percent) 44.7% (95% interval 30 to 60 percent) 41.7% (95% interval 27 to 58 percent)
    Auditory Effects 24.1% (95% interval 12 to 42 percent) 36.8% (95% interval 23 to 53 percent) 25.0% (95% interval 14 to 41 percent)
    Music Enhancement 27.6% (95% interval 15 to 46 percent) 28.9% (95% interval 17 to 45 percent) 36.1% (95% interval 22 to 52 percent)
    Dissociation 17.2% (95% interval 8 to 34 percent) 28.9% (95% interval 17 to 45 percent) 36.1% (95% interval 22 to 52 percent)
    Confusion 20.7% (95% interval 10 to 38 percent) 34.2% (95% interval 21 to 50 percent) 30.6% (95% interval 18 to 47 percent)
    Stimulation 27.6% (95% interval 15 to 46 percent) 26.3% (95% interval 15 to 42 percent) 30.6% (95% interval 18 to 47 percent)
    Introspection — 26.3% (95% interval 15 to 42 percent) 25.0% (95% interval 14 to 41 percent)
    Focus Enhancement 17.2% (95% interval 8 to 34 percent) 5.3% (95% interval 2 to 17 percent) 25.0% (95% interval 14 to 41 percent)
    Time Distortion — 15.8% (95% interval 7 to 30 percent) 25.0% (95% interval 14 to 41 percent)
    Body High 10.3% (95% interval 4 to 26 percent) 21.1% (95% interval 11 to 36 percent) 19.4% (95% interval 10 to 35 percent)

    Subjective Effect Ontology

    Experience Reports

    Structured effect tags extracted from 1,093 Erowid & Bluelight experience reports using a controlled vocabulary of 220+ canonical effects across 15 domains.

    Auditory

    music enhancement 330 30.2% (95% interval 28 to 33 percent) auditory distortions 278 26.7% (95% interval 24 to 29 percent)

    Cognitive

    confusion 314 28.7% (95% interval 26 to 32 percent) focus enhancement 270 25.9% (95% interval 23 to 29 percent) introspection 222 20.3% (95% interval 18 to 23 percent) memory suppression 112 10.2% (95% interval 8 to 12 percent)

    Emotional

    anxiety 587 53.7% (95% interval 51 to 57 percent) empathy 424 38.8% (95% interval 36 to 42 percent) euphoria 385 35.3% (95% interval 32 to 38 percent)

    Motor

    stimulation 373 34.2% (95% interval 32 to 37 percent)

    Selfhood

    dissociation 265 24.2% (95% interval 22 to 27 percent) ego dissolution 143 13.1% (95% interval 11 to 15 percent)

    Somatic

    body high 184 16.8% (95% interval 15 to 19 percent)

    Tactile

    tactile enhancement 277 26.6% (95% interval 24 to 29 percent)

    Temporal

    time distortion 146 13.4% (95% interval 12 to 16 percent)

    Visual

    visual distortions 788 72.1% (95% interval 69 to 75 percent) color enhancement 686 62.8% (95% interval 60 to 66 percent) closed eye visuals 376 34.4% (95% interval 32 to 37 percent) open eye visuals 116 10.6% (95% interval 9 to 13 percent)

    19 unique effects extracted · Derived from Erowid & Bluelight reports

    Dose–Effect Mapping

    Experience Reports

    How reported effects shift across dose tiers, based on 640 single-substance experience reports. The shaded band on each bar is its 95% interval. An arrow (↑ ↓) marks a change between the lowest and highest tier that count an effect only when the gap is bigger than chance would explain; ~ means no clear change. How changes are called

    Smoked dose range: 30.0–60.0 mg (median 50.0 mg)
    Effect Common (n=29) Strong (n=38) Heavy (n=36) Change with dose
    visual distortions
    69% (95% interval 51 to 83 percent)
    90% (95% interval 76 to 96 percent)
    78% (95% interval 62 to 88 percent)
    (no clear change: +9 points from Common to Heavy, 95% interval −12 to +30)
    color enhancement
    62% (95% interval 44 to 77 percent)
    71% (95% interval 55 to 83 percent)
    72% (95% interval 56 to 84 percent)
    (no clear change: +10 points from Common to Heavy, 95% interval −12 to +32)
    anxiety
    62% (95% interval 44 to 77 percent)
    55% (95% interval 40 to 70 percent)
    47% (95% interval 32 to 63 percent)
    (no clear change: −15 points from Common to Heavy, 95% interval −36 to +9)
    closed-eye visuals
    48% (95% interval 31 to 66 percent)
    47% (95% interval 32 to 63 percent)
    36% (95% interval 22 to 52 percent)
    (no clear change: −12 points from Common to Heavy, 95% interval −34 to +11)
    empathy
    34% (95% interval 20 to 53 percent)
    45% (95% interval 30 to 60 percent)
    44% (95% interval 30 to 60 percent)
    (no clear change: +10 points from Common to Heavy, 95% interval −14 to +32)
    euphoria
    21% (95% interval 10 to 38 percent)
    45% (95% interval 30 to 60 percent)
    42% (95% interval 27 to 58 percent)
    (no clear change: +21 points from Common to Heavy, 95% interval −2 to +40)
    auditory effects
    24% (95% interval 12 to 42 percent)
    37% (95% interval 23 to 53 percent)
    25% (95% interval 14 to 41 percent)
    (no clear change: +1 points from Common to Heavy, 95% interval −20 to +21)
    music enhancement
    28% (95% interval 15 to 46 percent)
    29% (95% interval 17 to 45 percent)
    36% (95% interval 22 to 52 percent)
    (no clear change: +8 points from Common to Heavy, 95% interval −14 to +29)
    dissociation
    17% (95% interval 8 to 34 percent)
    29% (95% interval 17 to 45 percent)
    36% (95% interval 22 to 52 percent)
    (no clear change: +19 points from Common to Heavy, 95% interval −3 to +38)
    confusion
    21% (95% interval 10 to 38 percent)
    34% (95% interval 21 to 50 percent)
    31% (95% interval 18 to 47 percent)
    (no clear change: +10 points from Common to Heavy, 95% interval −12 to +29)
    stimulation
    28% (95% interval 15 to 46 percent)
    26% (95% interval 15 to 42 percent)
    31% (95% interval 18 to 47 percent)
    (no clear change: +3 points from Common to Heavy, 95% interval −19 to +24)
    introspection —
    26% (95% interval 15 to 42 percent)
    25% (95% interval 14 to 41 percent)
    (no clear change: −1 points from Strong to Heavy, 95% interval −21 to +18)
    focus enhancement
    17% (95% interval 8 to 34 percent)
    5% (95% interval 2 to 17 percent)
    25% (95% interval 14 to 41 percent)
    (no clear change: +8 points from Common to Heavy, 95% interval −13 to +26)
    time distortion —
    16% (95% interval 7 to 30 percent)
    25% (95% interval 14 to 41 percent)
    (no clear change: +9 points from Strong to Heavy, 95% interval −9 to +27)
    body high
    10% (95% interval 4 to 26 percent)
    21% (95% interval 11 to 36 percent)
    19% (95% interval 10 to 35 percent)
    (no clear change: +9 points from Common to Heavy, 95% interval −10 to +26)
    memory suppression
    10% (95% interval 4 to 26 percent)
    8% (95% interval 3 to 21 percent)
    17% (95% interval 8 to 32 percent)
    (no clear change: +6 points from Common to Heavy, 95% interval −12 to +23)
    open-eye visuals —
    16% (95% interval 7 to 30 percent)
    6% (95% interval 2 to 18 percent)
    (no clear change: −10 points from Strong to Heavy, 95% interval −25 to +5)
    sedation — —
    11% (95% interval 4 to 25 percent)
    counted in the Heavy tier only
    tactile enhancement
    10% (95% interval 4 to 26 percent)
    5% (95% interval 2 to 17 percent)
    8% (95% interval 3 to 22 percent)
    (no clear change: −2 points from Common to Heavy, 95% interval −19 to +13)
    ego dissolution
    10% (95% interval 4 to 26 percent)
    5% (95% interval 2 to 17 percent)
    — (no clear change: −5 points from Common to Strong, 95% interval −22 to +9)

    Showing top 20 of 28 effects

    Risk Escalation

    Sentiment Analysis

    Average frequency of positive vs adverse effects across dose tiers. A tier's average is the mean share of the effects counted in that tier, not a share of reports, and its range is a deliberately wide 95% interval. A tier with more reports also counts rarer effects, which pulls its average down, so compare single effects in the breakdown rather than these averages. There, the shaded band on each bar is its 95% interval, and Change is marked up or down only when the gap between two tiers is bigger than chance would explain. How changes are called

    Common n=29
    10 positive 32.8% (95% interval 20 to 50 percent) 4 adverse 25.0% (95% interval 15 to 41 percent)
    Strong n=38
    12 positive 35.5% (95% interval 24 to 49 percent) 7 adverse 16.9% (95% interval 10 to 30 percent)
    Heavy n=36
    13 positive 33.1% (95% interval 22 to 48 percent) 5 adverse 21.1% (95% interval 12 to 36 percent)
    View effect breakdown

    Adverse Effects

    Effect Common (n=29) Strong (n=38) Heavy (n=36) Change
    Anxiety
    62% (95% interval 44 to 77 percent)
    55% (95% interval 40 to 70 percent)
    47% (95% interval 32 to 63 percent)
    no clear change (no clear change: −15 points from Common to Heavy, 95% interval −36 to +9)
    Confusion
    21% (95% interval 10 to 38 percent)
    34% (95% interval 21 to 50 percent)
    31% (95% interval 18 to 47 percent)
    no clear change (no clear change: +10 points from Common to Heavy, 95% interval −12 to +29)
    Memory Suppression
    10% (95% interval 4 to 26 percent)
    8% (95% interval 3 to 21 percent)
    17% (95% interval 8 to 32 percent)
    no clear change (no clear change: +6 points from Common to Heavy, 95% interval −12 to +23)
    Headache
    7% (95% interval 2 to 22 percent)
    — — —
    Increased Heart Rate —
    5% (95% interval 2 to 17 percent)
    6% (95% interval 2 to 18 percent)
    no clear change (no clear change: +0.3 points from Strong to Heavy, 95% interval −12 to +13)
    Thought Loops — —
    6% (95% interval 2 to 18 percent)
    —
    Motor Impairment —
    5% (95% interval 2 to 17 percent)
    — —
    Nausea —
    5% (95% interval 2 to 17 percent)
    — —
    Jaw Clenching —
    5% (95% interval 2 to 17 percent)
    — —

    Positive Effects

    Effect Common (n=29) Strong (n=38) Heavy (n=36) Change
    Visual Distortions
    69% (95% interval 51 to 83 percent)
    90% (95% interval 76 to 96 percent)
    78% (95% interval 62 to 88 percent)
    no clear change (no clear change: +9 points from Common to Heavy, 95% interval −12 to +30)
    Color Enhancement
    62% (95% interval 44 to 77 percent)
    71% (95% interval 55 to 83 percent)
    72% (95% interval 56 to 84 percent)
    no clear change (no clear change: +10 points from Common to Heavy, 95% interval −12 to +32)
    Closed-Eye Visuals
    48% (95% interval 31 to 66 percent)
    47% (95% interval 32 to 63 percent)
    36% (95% interval 22 to 52 percent)
    no clear change (no clear change: −12 points from Common to Heavy, 95% interval −34 to +11)
    Empathy
    34% (95% interval 20 to 53 percent)
    45% (95% interval 30 to 60 percent)
    44% (95% interval 30 to 60 percent)
    no clear change (no clear change: +10 points from Common to Heavy, 95% interval −14 to +32)
    Euphoria
    21% (95% interval 10 to 38 percent)
    45% (95% interval 30 to 60 percent)
    42% (95% interval 27 to 58 percent)
    no clear change (no clear change: +21 points from Common to Heavy, 95% interval −2 to +40)
    Music Enhancement
    28% (95% interval 15 to 46 percent)
    29% (95% interval 17 to 45 percent)
    36% (95% interval 22 to 52 percent)
    no clear change (no clear change: +8 points from Common to Heavy, 95% interval −14 to +29)
    Stimulation
    28% (95% interval 15 to 46 percent)
    26% (95% interval 15 to 42 percent)
    31% (95% interval 18 to 47 percent)
    no clear change (no clear change: +3 points from Common to Heavy, 95% interval −19 to +24)
    Introspection —
    26% (95% interval 15 to 42 percent)
    25% (95% interval 14 to 41 percent)
    no clear change (no clear change: −1 points from Strong to Heavy, 95% interval −21 to +18)
    Focus Enhancement
    17% (95% interval 8 to 34 percent)
    5% (95% interval 2 to 17 percent)
    25% (95% interval 14 to 41 percent)
    no clear change (no clear change: +8 points from Common to Heavy, 95% interval −13 to +26)
    Body High
    10% (95% interval 4 to 26 percent)
    21% (95% interval 11 to 36 percent)
    19% (95% interval 10 to 35 percent)
    no clear change (no clear change: +9 points from Common to Heavy, 95% interval −10 to +26)
    Open-Eye Visuals —
    16% (95% interval 7 to 30 percent)
    6% (95% interval 2 to 18 percent)
    no clear change (no clear change: −10 points from Strong to Heavy, 95% interval −25 to +5)
    Tactile Enhancement
    10% (95% interval 4 to 26 percent)
    5% (95% interval 2 to 17 percent)
    8% (95% interval 3 to 22 percent)
    no clear change (no clear change: −2 points from Common to Heavy, 95% interval −19 to +13)
    Creativity Enhancement — —
    8% (95% interval 3 to 22 percent)
    —

    Dosage Distribution

    Dose distribution from experience reports, one dose per report (the first listed). Doses above Q3 + 3×IQR, far above what people typically take, are left out of the median and range and listed under each route: most are real heavy doses or overdoses, not mistakes.

    Smoked

    Median: 50.0 mg IQR: 30.0–60.0 mg n=191

    6 reports gave a dose above the typical range (160–750 mg), so they are not in the figures above. Listing a dose here does not mean it is safe.

    Show the reports

    Insufflated

    Median: 60.0 mg IQR: 35.0–82.5 mg n=11

    Real-World Dose Distribution

    Erowid

    From 516 of 1008 recorded dose entries: those that state a weight (mg, g or µg), in routes with at least five of them. Values above Q3 + 3×IQR, far above what people typically take, are left out; they can include real heavy doses and overdoses, not only mistakes.

    Smoked (n=423)

    Median: 42.0mg 25th: 30.0mg 75th: 60.0mg 90th: 94.0mg

    Oral (n=54)

    Median: 80.0mg 25th: 50.0mg 75th: 163.75mg 90th: 250.0mg

    Intravenous (n=9)

    Median: 32.0mg 25th: 22.0mg 75th: 60.0mg 90th: 60.0mg

    Insufflated (n=15)

    Median: 55.0mg 25th: 32.5mg 75th: 82.5mg 90th: 96.0mg

    Common Combinations

    Most co-occurring substances, as a share of all 1,043 reports filed under DMT; whiskers are 95% intervals

    Form / Preparation

    Most common forms and preparations, as a share of the 447 reports that give one; whiskers are 95% intervals

    Body-Weight Dosing

    Dose per kg of body weight, one dose per report (the first listed), from reports giving a weight of 30–250 kg. Doses above Q3 + 3×IQR, far above what people typically take, are left out of the median and range and listed under each route.

    Smoked

    Median: 0.611 mg/kg IQR: 0.416–0.854 mg/kg n=188

    6 reports gave a dose above the typical range (2.273–10 mg/kg), so they are not in the figures above. Listing a dose here does not mean it is safe.

    Show the reports

    Oral

    Median: 1.472 mg/kg IQR: 0.84–2.928 mg/kg n=6

    Insufflated

    Median: 0.954 mg/kg IQR: 0.713–1.466 mg/kg n=10

    Redose Patterns

    Redosing behavior across 554 reports

    10.3% (95% interval 8 to 13 percent) Redosed
    1.1 Avg Doses
    60m Median Interval

    Legal Status

    UN Convention on Psychotropic Substances 1971 (Schedule I)
    Country Status Notes
    Brazil Legal (religious use of ayahuasca) Brazilian law was adjusted in 1996 to permit the religious use of ayahuasca following a legal challenge from the União do Vegetal church. This exemption applies specifically to traditional ceremonial contexts. Synthetic DMT remains controlled.
    Canada Schedule III Listed as a Schedule III controlled substance under the Controlled Drugs and Substances Act. This scheduling carries criminal penalties for unauthorized possession and trafficking.
    New Zealand Class A Controlled under the Misuse of Drugs Act 1975. Class A drugs carry the highest penalties under New Zealand drug legislation.
    United Kingdom Class A Controlled under the Misuse of Drugs Act. Class A substances carry the most severe penalties for possession, production, and distribution.
    United States Schedule I Controlled under the Controlled Substances Act of 1970. Classified as having high abuse potential with no accepted medical use. However, in 2006 the Supreme Court ruled that the União do Vegetal (UDV) church could use their ayahuasca brew for religious purposes despite DMT's Schedule I status, based on the 1993 Religious Freedom Restoration Act.

    Harm Reduction

    drugs.wiki

    - Test and verify substance identity: DMT is an indole and typically reacts positive with indole-sensitive reagents (e.g., Ehrlich), but reagent color alone cannot prove purity; formal drug checking is preferred. Mislabeling between N,N-DMT and 5-MeO-DMT has led to overdoses due to very different potency and effects profiles.

    - Vaporization technique matters: use heat, not direct flame; pre-measure with a mg-accurate scale; expect that melted residue can linger in glassware and cause unexpected extra milligrams later. Sit or lie down before the last inhalation to avoid falls due to rapid incapacitation.

    - Cardiovascular effects (transient hypertension/tachycardia) are common at psychoactive doses; screen for uncontrolled hypertension, significant cardiac disease, or recent stimulant use; avoid combining with vasopressors or strong stimulants.

    - Oral DMT requires MAO-A inhibition; this markedly increases duration/intensity and interaction risks. Avoid serotonergic medications (SSRIs/SNRIs/TCAs), tramadol, meperidine, DXM, and stimulant drugs for an adequate washout period when MAOIs are involved. Some foods high in tyramine can pose added risk with prescription/strong MAOIs.

    - Mental health cautions: strong psychedelics can precipitate or exacerbate psychosis or mania in vulnerable individuals; those with personal/family history of psychotic or bipolar disorders should avoid or proceed only with clinical oversight.

    - Sitter and environment: due to near-instant onset, a sober sitter should remove hot devices and protect from falls. Use in a quiet, seated/lying setting with minimal obstacles.

    - Avoid redosing loops: acute tolerance is minimal with DMT compared to LSD/psilocybin; however, repeated back-to-back inhalations can stack cardiovascular/psychological load without providing integration time.

    - Changa (DMT on MAOI-containing herbs) typically requires slightly lower DMT doses and lasts longer than freebase alone; interaction cautions of harmalas apply.

    - Pulmonary irritation is common with hot or combusted vapor; lower-temperature vaporization and cooling the vapor (e.g., water piece) can reduce airway discomfort; individuals with reactive airway disease should be cautious.

    - Distinguish N,N-DMT from 5-MeO-DMT: 5-MeO-DMT is active at much lower doses and carries higher risk of severe adverse reactions, particularly with MAOIs. Never assume marketed “DMT” is N,N-DMT; verify before dosing.

    - Drug checking services (where available) can detect adulterants and misrepresentation; several European services have reported misdeclared tryptamine products, underscoring the need for verification before use.

    References

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