Deschloroketamine Stats & Data

Measured binding and functional data for S-deschloroketamine, curated by the IUPHAR/BPS Guide to PHARMACOLOGY. Each row cites the paper it came from. Lower concentrations mean tighter binding — a value in the sub-nanomolar range indicates a very potent interaction.

Reading this. pKi, pEC50 and pIC50 are negative log molar values, so a higher number means a tighter interaction; the concentration column converts them for you. Values from non-human species are laboratory measurements and do not translate directly to human effect. Receptor affinity is not a dose — it describes what a molecule binds, not how much of it is safe to take.

Receptor data from the IUPHAR/BPS Guide to PHARMACOLOGY (v2026.2), licensed CC BY-SA 4.0. Matched to this substance by InChIKey.

Forked from Subjective Effect Documentation work by Josie Kins, August 2016. Via dose.wiki (CC0).

The toxicity and long-term health effects of recreational DCK use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because DCK has very little history of human usage. Anecdotal evidence from people who have tried DCK within the community suggests that there do not seem to be any negative health effects attributed to simply trying this drug at low to moderate doses by itself and using it sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption. As DCK has been speculated to have antibacterial properties, its prolonged use could potentially pose a serious threat to one's health and immune system.

Effects aggregated from 12 experience reports (12 single-substance Erowid)

Each bar is the share of reports mentioning the effect; its whisker, and the band on the rows below, is the 95% interval: where the share could plausibly be with other reports of the same kind.

Too few reports for bars: these effects come from 12 single-substance Erowid reports, and a bar is drawn only from 20 reports or more. With fewer, a percentage cannot tell a common effect from a rare one. Counts are shown instead. Why 20?

Also reported in combinations. In the 19 Deschloroketamine reports where another drug was taken too, 0 mention hospital, emergency services or an overdose, 0 a seizure and 3 psychosis (too few reports for percentages). In the 12 single-substance reports: 2, 0 and 1. These are not in the figures above: they cannot be put down to Deschloroketamine alone, and a mention is not always something that happened to the writer.

From 63 of 70 recorded dose entries: those that state a weight (mg, g or µg), in routes with at least five of them. Values above Q3 + 3×IQR, far above what people typically take, are left out; they can include real heavy doses and overdoses, not only mistakes.

Most co-occurring substances, as a share of all 31 reports filed under Deschloroketamine; whiskers are 95% intervals

Most common forms and preparations, as a share of the 27 reports that give one; whiskers are 95% intervals

Dose per kg of body weight, one dose per report (the first listed), from reports giving a weight of 30–250 kg. Doses above Q3 + 3×IQR, far above what people typically take, are left out of the median and range and listed under each route.

Redosing behavior across 28 reports