Cyclopentyl-Fentanyl
Limited data
Limited data
Sparse data. Doses and effects may be unreliable or untested.
- 1 source
- no dose data
- 29 combo interactions documented
- classified Tentative
- classified Research-chemical
- 1 source
- no dose data
- 29 combo interactions documented
- classified Tentative
- classified Research-chemical
Aliases: Cp-f, cpf
Summary
Cyclopentylfentanyl is a fentanyl analogue and a full ฮผ-opioid agonist, with published receptor pharmacology (EC50 around 13 nM, ~92% efficacy). It has been identified in fatal overdose casework. No human dose is established, and it should be assumed to carry fentanyl-scale lethality โ active in micrograms, with respiratory depression as the mechanism of death. Naloxone works but repeat doses are commonly required.
Tolerance
No tolerance chart. Our decay curves for opioids were estimates, and a curve can make tolerance look longer-lasting than it is, which is the dangerous direction.
Opioid tolerance drops fast when you stop, and even a few days off can be enough, so a dose that used to be normal can now stop your breathing. Overdose deaths rise sharply after prison, detox or leaving treatment, and tolerance also falls during a hospital stay. After any break, start with a much smaller amount, try a test dose first, don't use alone, and keep naloxone within reach. Alcohol, benzodiazepines, gabapentinoids and other sedatives make an opioid overdose much more likely.
Sources: FRANK: heroin ยท National Harm Reduction Coalition ยท WHO: opioid overdose ยท Merrall et al. 2010 ยท Binswanger et al. 2007 ยท Strang et al. 2003 ยท FDA 2019: gabapentinoids and breathing
Combinations
Cross-Check Cyclopentyl-Fentanyl with another substanceHelpful Links
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