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    CBG molecular structure

    CBG Stats & Data

    PubChem
    MW316.5
    FormulaC21H32O2
    LogP7.4
    IUPAC2-[(2E)-3,7-dimethylocta-2,6-dienyl]-5-pentylbenzene-1,3-diol
    InChIKeyQXACEHWTBCFNSA-SFQUDFHCSA-N
    Chemical Class Phytocannabinoid
    Half-Life ~4 – 6 h (tentative; human data sparse). Inhalation likely shorter due to faster distribution/elimination.

    Measured Affinities

    Guide to PHARMACOLOGY

    Measured binding and functional data for cannabigerol, curated by the IUPHAR/BPS Guide to PHARMACOLOGY. Each row cites the paper it came from. Lower concentrations mean tighter binding — a value in the sub-nanomolar range indicates a very potent interaction.

    Target Action Measure Value Concentration Species Source
    TRPM8 Trpm8 Antagonist pIC50 6.8 158.49 nM Rat PMID 38408345
    TRPA1 Trpa1 Agonist pEC50 6.15 707.95 nM Rat PMID 38408345
    Nav1.7 SCN9A Channel blocker pIC50 5.34 4,571 nM Human PMID 35297036
    Nav1.8 SCN10A Channel blocker pIC50 5.3 5,012 nM Human PMID 39835903
    Nav1.7 SCN9A Channel blocker pIC50 4.73 18,621 nM Human PMID 35297036
    TRPM8 Trpm8 Antagonist - — — Rat PMID 21902175

    Reading this. pKi, pEC50 and pIC50 are negative log molar values, so a higher number means a tighter interaction; the concentration column converts them for you. Values from non-human species are laboratory measurements and do not translate directly to human effect. Receptor affinity is not a dose — it describes what a molecule binds, not how much of it is safe to take.

    Receptor data from the IUPHAR/BPS Guide to PHARMACOLOGY (v2026.2), licensed CC BY-SA 4.0. Matched to this substance by InChIKey.

    Tolerance & Pharmacokinetics

    drugs.wiki
    Half-Life
    ~4 – 6 h (tentative; human data sparse). Inhalation likely shorter due to faster distribution/elimination.
    Addiction Potential
    Very low; no evidence of compulsive use or withdrawal. Dependence has not been documented in humans.

    Tolerance Decay

    Full tolerance 10d Half tolerance 14d Baseline ~21d

    Estimates extrapolated from general cannabinoid use patterns and user reports; formal human CBG tolerance data are lacking.

    Cross-Tolerances

    Other phytocannabinoids (CBD, THC, CBN)
    30% ●○○

    Harm Reduction

    drugs.wiki

    • CBG appears non-intoxicating and clear-headed for most users, but human clinical evidence remains limited; treat it as an experimental supplement rather than a proven therapy.

    • Quality control varies widely across hemp-derived products; insist on a recent third-party COA reporting potency (CBG/THC), residual solvents, pesticides, heavy metals, and microbial contaminants. Mislabeling and contamination have been repeatedly documented in cannabinoid products.

    • To avoid unintended intoxication or drug testing issues, verify Δ9-THC is below legal thresholds in the final product (not just the source hemp) and be mindful that even trace THC can accumulate with frequent dosing.

    • Like other lipophilic cannabinoids, oral exposure can be increased by high-fat meals. If you change meal fat content, re-titrate from a lower dose to avoid overshooting effects.

    • Cannabinoids can cause transient postural hypotension and dry mouth/eyes; sit or lie down if lightheaded. Those on antihypertensives or α2-agonists (e.g., clonidine; brimonidine eye drops) should start at the low end and monitor blood pressure.

    • Avoid driving or operating machinery until you know your response—drowsiness can occur at higher doses or with CNS depressants.

    • Inhalation: avoid oils and thickeners (e.g., vitamin E acetate) and unknown diluents; use tested distillates only, at modest temperatures, to reduce thermal degradation products.

    • Pregnancy/breastfeeding: cannabinoid exposure in pregnancy is associated with risks with THC-containing products; there are insufficient data for CBG. Best practice is to avoid unless medically justified.

    • Pilot and preclinical data suggest potential anxiolytic and anti-inflammatory actions, but CBG is not a substitute for indicated treatments in serious conditions. Discuss with a clinician if using alongside prescription medicines.

    • Human pharmacokinetics are not well established; expect interindividual variability and adjust intervals/doses conservatively.

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