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    Amineptine molecular structure

    Amineptine Stats & Data

    Maneon Directin Survector
    PubChem
    MW337.5
    FormulaC22H27NO2
    LogP2.1
    IUPAC7-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylamino)heptanoic acid
    InChIKeyONNOFKFOZAJDHT-UHFFFAOYSA-N
    Chemical Class Dibenzocycloheptene
    Psychoactive Class Depressant

    Pharmacology

    DrugBank
    State Solid Metabolism Hepatic.

    Description

    The Food and Drug Administration suspended the marketing authorisation for Survector in 1999 and France withdrew it from the market, however several developing countries continued to produce it up until 2005.

    Mechanism of Action

    Amineptine selectively inhibits the reuptake of dopamine and to a lesser extent norepinephrine, thus exerting a powerful and fast-acting antidepressant effect.

    Pharmacodynamics

    Amineptine is an atypical tricyclic antidepressant.

    Indication

    For the treatment of depression.

    Half-life

    48 minutes for the parent drug and 2.5 hours for the metabolites.

    Toxicity

    PubChem

    Liver injury risk

    High concern (frequent serious cases reported)

    FDA LiverTox / DILIrank. Reflects published case reports of liver injury, not absolute risk.

    Tolerance & Pharmacokinetics

    drugs.wiki

    Tolerance Decay

    Full tolerance 1h Half tolerance 10d Baseline ~14d

    Experience Report Analysis

    Erowid
    1 Reports
    2004–2004 Date Range

    Demographics

    Gender Distribution

    Too few reports for a chart: gender is known from 1 report, and a split is drawn only from 20 reports or more. Counts are shown instead. Why 20?

    • Male 1 of 1

    Reports Over Time

    Real-World Dose Distribution

    Erowid

    From 5 of 5 recorded dose entries: those that state a weight (mg, g or µg), in routes with at least five of them. Values above Q3 + 3×IQR, far above what people typically take, are left out; they can include real heavy doses and overdoses, not only mistakes.

    Oral (n=5)

    Median: 100.0mg 25th: 25.0mg 75th: 200.0mg 90th: 200.0mg
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