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    ๐Ÿงช This is a research chemical with limited data on its long-term health effects, toxicity profile, and safe dosage ranges.

    5-MeO-AMT Well-documented
    Well-documented
    Multiple authoritative sources agree on dosing and effects.
    • 5 corroborating sources
    • 1 ROA with full dose ladder
    • duration data present
    • 27 combo interactions documented
    • classified Research-chemical

    Aliases: Alpha, Alpha-o, ฮฑ,o-dms, ฮฑ,o-dimethylserotonin, 5meoamt, 5-MeO-ฮฑMT

    Psychedelic Stimulant Empathogen Research-chemical

    Summary dose.wiki Erowid TripSit

    One of the most potent psychedelic tryptamines known, requiring extreme caution with dosing. Highly dose-sensitive with medical emergencies reported at doses as low as 8 mg oral. Has been misrepresented as LSD on blotter and gelatin tabs, leading to multiple hospitalizations and deaths.

    Dose Information dose.wiki TripSit

    ROA Light Common Strong Heavy
    Oral 1-2mg 2-4mg 4-6mg 6mg+
    Light Common Strong Heavy
    Sources

    Oral

    Dose ladder — dose.wiki, TripSit
    โš  from 5โ€“8 mg oral Medical emergencies reported

    “Dose sensitivity is extreme at the milligram level; 5-8 mg oral has been associated with medical emergencies in community reports.” — dose.wiki (community reports)

    Onset, Duration & After-effects dose.wiki TripSit

    ROA Onset Comeup Peak Offset After Effects Total
    Oral 0.5-2 hrs 1-2 hrs 3-8 hrs 3-6 hrs 4-24 hrs 7.5-18 hrs
    Insufflated 4-19 min 19-40 min 3-8 hrs 3-6 hrs 4-24 hrs 6.39-14.99 hrs
    Rectal 4-19 min 30-60 min 3-8 hrs 3-6 hrs 4-24 hrs 6.57-15.32 hrs

    Effect Profile

    96 reports

    Scores (0–10) curated from multiple sources:

    • Effect keyword matching from PsychonautWiki catalog
    • Validated against 88 Erowid trip reports
    • Weighted by importance: core (×3), major (×2), minor (×1)

    Full methodology

    Psychedelic 6.1
    Strong 6/10

    Strong visuals and auditory effects with strong body load, low headspace

    Visual Intensity ×3
    10
    color enhancement pattern recognition enhancement brightened colour
    Headspace Depth ×3
    3
    confusion
    Auditory Effects ×1
    10
    auditory enhancement
    ⚠ Body Load / Somatic Effects ×1
    10
    temperature regulation suppression nausea muscle tension jaw clenching
    Empathogen 9.3
    Intense+ 9/10

    Strong empathy, sensory enhancement, stimulation, and euphoria

    Empathy / Social Openness ×3
    10
    empathy enhancement empathy sociability enhancement
    Euphoria / Mood Elevation ×2
    8
    euphoria mood elevation
    Stimulation ×1
    9
    physical stimulation mental stimulation restlessness
    Sensory Enhancement ×1
    10
    tactile enhancement enhanced tactile sensation color enhancement
    Stimulant 5.0
    Moderate+ 5/10

    Strong stimulation with strong anxiety/jitters, moderate euphoria, low focus

    Stimulation / Energy ×3
    8
    physical stimulation mental stimulation
    Euphoria / Mood Lift ×2
    7
    euphoria mood elevation
    Focus / Productivity ×2
    1
    ⚠ Anxiety / Jitters ×1
    10
    anxiety restlessness jaw clenching muscle tension
    Based on reports from:
    Bluelight Big & Dandy Thread Erowid Experience Reports
    View methodology →

    Tolerance

    Build-up develops rapidly after a single use
    Reset 7โ€“14 days for baseline

    Tolerance Decay

    Half tolerance 7d Baseline ~10d

    Animal data show rapid tolerance to head-twitch with repeated dosing; users commonly report diminished effects for several days after use with partial recovery by ~3 days and near-baseline after ~10โ€“14 days. Cross-tolerance with classic psychedelics is expected given shared 5โ€‘HT2A agonism, but human quantification is lacking.

    Cross-Tolerances

    LSD
    Psilocybin
    DMT

    Effects Erowid Bluelight

    Aggregated from 88 single-substance Erowid and 8 Bluelight experience reports; 48 Erowid reports where another drug was taken too are left out

    Each bar shows the share of analyzed reports whose text mentions that effect — a mention is not always a first-hand experience (fear of an effect or something witnessed can count). Mentions saying the effect did not happen are left out; that check reads keywords, so it can miss some. The shaded band on a bar, and the small range after its number, is the 95% interval: where the share could plausibly be with other reports of the same kind. Fewer reports, wider band. Tap or hover any number for details. The second value is the Bluelight extractor's per-effect confidence; a dash means the row is Erowid-derived, which has no confidence measurement.

    Rows resting on fewer than 20 reports show a count (“3 of 7”) instead of a bar. Why 20?

    Positive Effects 33

    67.7% (95% interval 58 to 76 percent) 80%
    31.3% (95% interval 23 to 41 percent) 81%
    31.2% (95% interval 23 to 41 percent) 84%
    30.2% (95% interval 22 to 40 percent) 86%
    22.9% (95% interval 16 to 32 percent) 90%
    14.8% (95% interval 9 to 24 percent) –
    14.6% (95% interval 9 to 23 percent) 80%
    13.5% (95% interval 8 to 22 percent) 85%
    10.4% (95% interval 6 to 18 percent) 80%
    10.4% (95% interval 6 to 18 percent) 75%
    6.3% (95% interval 3 to 13 percent) 75%
    5.7% (95% interval 2 to 13 percent) –
    3 of 8 87%
    3 of 8 83%
    3 of 8 80%
    3 of 8 85%
    3 of 8 83%
    2 of 8 88%
    2 of 8 80%
    2 of 8 82%
    Show 13 more positive effects
    2 of 8 78%
    2 of 8 82%
    1 of 8 80%
    1 of 8 85%
    1 of 8 70%
    1 of 8 85%
    1 of 8 80%
    1 of 8 80%
    1 of 8 75%
    1 of 8 85%
    1 of 8 80%
    1 of 8 80%
    1 of 8 70%

    Adverse Effects 44

    52.1% (95% interval 42 to 62 percent) 87%
    41.7% (95% interval 32 to 52 percent) 78%
    20.5% (95% interval 13 to 30 percent) –
    Auditory Effects 19.8% (95% interval 13 to 29 percent) 90%
    11.5% (95% interval 6 to 19 percent) 95%
    10.2% (95% interval 6 to 18 percent) –
    9.4% (95% interval 5 to 17 percent) 75%
    6.8% (95% interval 3 to 14 percent) –
    6.8% (95% interval 3 to 14 percent) –
    6.8% (95% interval 3 to 14 percent) –
    5.2% (95% interval 2 to 12 percent) 90%
    4.5% (95% interval 2 to 11 percent) –
    4.5% (95% interval 2 to 11 percent) –
    5 of 8 81%
    3 of 8 92%
    3 of 8 82%
    3 of 8 88%
    2 of 8 90%
    2 of 8 82%
    1 of 8 75%
    1 of 8 85%
    Show 23 more adverse effects
    1 of 8 75%
    1 of 8 75%
    1 of 8 70%
    1 of 8 80%
    1 of 8 80%
    1 of 8 75%
    1 of 8 85%
    1 of 8 95%
    1 of 8 95%
    1 of 8 90%
    1 of 8 95%
    1 of 8 95%
    1 of 8 85%
    1 of 8 75%
    1 of 8 85%
    1 of 8 65%
    1 of 8 80%
    1 of 8 80%
    1 of 8 85%
    1 of 8 75%
    1 of 8 90%
    1 of 8 85%
    1 of 8 85%

    Also reported in combinations. In the 48 5-MeO-AMT reports where another drug was taken too, 6 (12.5%) mention hospital, emergency services or an overdose, 0 (0.0%) a seizure and 1 (2.1%) psychosis. In the 88 single-substance reports: 21.6%, 4.5% and 4.5%. These are not in the figures above: they cannot be put down to 5-MeO-AMT alone, and a mention is not always something that happened to the writer.

    Combinations

    Cross-Check 5-MeO-AMT with another substance

    Bluelight Reference Guide Bluelight

    The Big & Dandy 5-MeO-AMT Thread

    Anyone got any tips on how to prevent diarrhea/intestinal problems with 5-MeO-AMT?

    Read full thread on Bluelight โ†’
    5-MeO-AMT's nerd page Pharmacology, chemical data, effect profiles, and more
    →

    Helpful Links

    ๐Ÿ“˜ Experience Reports ๐Ÿ“– dose.wiki ๐Ÿ“– Bluelight ๐Ÿ“– PsychonautWiki
    Add to PsychonautWiki Journal

    The PsychonautWiki Journal logging app doesn't include every substance. To track 5-MeO-AMT there, start adding an ingestion, search for the name, and choose to add it as a custom substance. Paste these values:

    ⬇ Download import file Import this file as custom substances and you get "5-MeO-AMT (Substance Search)" with every route's full dose ladder and timeline, no typing. Works on iOS and Android (v15+); the format is confirmed by the app's developer. The manual values below work for older versions.
    Name
    5-MeO-AMT
    Unit
    mg
    Description 
    5-MeO-AMT
Source: SubstanceSearch (substancesearch.com)

Oral dose (mg): threshold 0.5-1 ยท light 1-2 ยท common 2-4 ยท strong 4-6 ยท heavy 6+

Oral duration: onset 0.5-2h ยท come-up 1-2h ยท peak 3-8h ยท offset 3-6h ยท total 7.5-18h ยท after-effects 4-24h
Insufflated duration: onset 4-19m ยท come-up 19-40m ยท peak 3-8h ยท offset 3-6h ยท total 6.39-14.99h ยท after-effects 4-24h
Rectal duration: onset 4-19m ยท come-up 0.5-1h ยท peak 3-8h ยท offset 3-6h ยท total 6.57-15.32h ยท after-effects 4-24h

Note: ranges are harm-reduction guidance, not a prescription. Start low, go slow, and test your substances.

    Tip: for quicker logging you can also add a Custom Unit in the app, e.g. common dose ~ 3 mg (Oral).

    The app keeps custom substances simple, so the full dose ranges live in the description text above. Ranges are harm-reduction guidance, not a prescription.