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    4-AcO-DiPT molecular structure

    4-AcO-DiPT Stats & Data

    Ace Aces 4-ace Ipracetin Iprocetyl 4-acetoxy-dipt 4acodipt
    NPS DataHub
    MW302.42
    FormulaC18H26N2O2
    CAS936015-60-0
    IUPAC[3-[2-(di(propan-2-yl)amino)ethyl]-1H-indol-4-yl] acetate
    SMILESCC(=O)Oc1cccc2ncc(CCN(C(C)C)C(C)C)c12
    InChIKeyZPAOVGZYDSXCPK-UHFFFAOYSA-N
    Chemical Class Substituted tryptamine
    Psychoactive Class Psychedelic

    Receptor Profile

    Receptor Actions

    Agonists
    5-HT2A receptor agonist (full)
    5-HT2C receptor agonist (full)

    History & Culture

    4-AcO-DiPT was first characterized in the scientific literature by Alexander Shulgin, with documentation appearing by 2003. The compound is described in TiHKAL (Tryptamines I Have Known and Loved), Shulgin's comprehensive reference work on tryptamine compounds co-authored with Ann Shulgin. The substance represents one of the early psychedelic research chemicals that emerged following Shulgin's initial synthesis and documentation, predating the widespread proliferation of online research chemical vendors that would later characterize the early 2000s market. It was first identified as a novel designer drug in 2005, marking its appearance in recreational and research contexts outside of Shulgin's laboratory work.

    Subjective Effects

    Physical
    • Bodily control enhancement
    • Increased heart rate
    • Nausea
    • Pupil dilation
    • Spontaneous tactile sensations
    • Tactile enhancement
    Cognitive
    • Analysis enhancement
    • Conceptual thinking
    • Creativity enhancement
    • Delusions
    • Emotion enhancement
    • Immersion enhancement
    • Memory suppression
    • Mindfulness
    • Novelty enhancement
    • Personal bias suppression
    • Spirituality enhancement
    • Thought acceleration
    • Thought disorganization
    • Thought loops
    • Time distortion
    • Unity and interconnectedness
    • Wakefulness
    • Ego death
    Sensory
    Auditory
    • Enhancements
    • Distortions
    • Hallucinations
    Visual · Distortions
    • Drifting: (melting, breathing, morphing and flowing)
    • Colour shifting
    • Depth perception distortions
    • Perspective distortions
    • Symmetrical texture repetition
    • Tracers
    Visual · Enhancements
    • Colour enhancement
    • Pattern recognition enhancement
    • Visual acuity enhancement
    Visual · Hallucinatory States
    • Transformations
    • Internal hallucinations: (autonomous entities; settings, sceneries, and landscapes; alterations in perspective and scenarios and plots)

    Forked from Subjective Effect Documentation work by Josie Kins, August 2016. Via dose.wiki (CC0).

    Toxicity

    PsychonautWiki

    The toxicity and long-term health effects of recreational 4-AcO-DiPT use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because 4-AcO-DiPT is a research chemical with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried 4-AcO-DiPT suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (although nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption. It is strongly recommended that one use harm reduction practices when using this drug.

    Effect Profile

    Curated + 32 Reports
    Psychedelic 7.2

    Strong visuals and auditory effects with strong body load, moderate headspace

    Visual Intensity×3
    1010
    Headspace Depth×3
    67.9
    Auditory Effects×1
    1010
    Body Load / Somatic Effects×1
    106.5
    Catalog Erowid

    Tolerance & Pharmacokinetics

    drugs.wiki

    Tolerance Decay

    Full tolerance 1h Half tolerance 10d Baseline ~14d

    Cross-Tolerances

    LSD
    Psilocybin
    Psilocin
    Mescaline
    DMT
    5-MeO-DMT
    2C-B
    2C-E

    Experience Report Analysis

    Erowid
    47 Reports
    32 Single-substance
    1999–2012 Date Range
    6 With Age Data
    24 Effects Detected

    Demographics

    Gender Distribution

    Age Distribution

    Reports Over Time

    Effect Analysis

    Erowid

    Effects aggregated from 32 experience reports (32 single-substance Erowid)

    32 Reports
    24 Effects Detected
    12 Positive
    7 Adverse
    5 Neutral

    Effect Sentiment Distribution

    Confidence Distribution

    Each bar is the share of reports mentioning the effect; its whisker, and the band on the rows below, is the 95% interval: where the share could plausibly be with other reports of the same kind.

    Positive Effects 12

    Visual Distortions 75.0% (95% interval 58 to 87 percent) 70%
    Empathy 59.4% (95% interval 42 to 74 percent) 70%
    Stimulation 50.0% (95% interval 34 to 66 percent) 70%
    Music Enhancement 46.9% (95% interval 31 to 64 percent) 70%
    Tactile Enhancement 37.5% (95% interval 23 to 55 percent) 70%
    Euphoria 37.5% (95% interval 23 to 55 percent) 70%
    Color Enhancement 34.4% (95% interval 20 to 52 percent) 70%
    Body High 25.0% (95% interval 13 to 42 percent) 70%
    Introspection 21.9% (95% interval 11 to 39 percent) 70%
    Closed-Eye Visuals 21.9% (95% interval 11 to 39 percent) 70%
    Open-Eye Visuals 15.6% (95% interval 7 to 32 percent) 70%
    Focus Enhancement 9.4% (95% interval 3 to 24 percent) 70%

    Adverse Effects 7

    Anxiety 31.2% (95% interval 18 to 49 percent) 70%
    Confusion 28.1% (95% interval 16 to 45 percent) 70%
    Muscle Tension 25.0% (95% interval 13 to 42 percent) 70%
    Nausea 15.6% (95% interval 7 to 32 percent) 70%
    Increased Heart Rate 12.5% (95% interval 5 to 28 percent) 70%
    Pupil Dilation 12.5% (95% interval 5 to 28 percent) 70%
    Motor Impairment 12.5% (95% interval 5 to 28 percent) 70%
    Show 5 neutral or unclassified mentions
    Sedation 25.0% (95% interval 13 to 42 percent)
    Auditory Effects 21.9% (95% interval 11 to 39 percent)
    Ego Dissolution 18.8% (95% interval 9 to 35 percent)
    Dissociation 18.8% (95% interval 9 to 35 percent)
    Hospital 9.4% (95% interval 3 to 24 percent)

    Also reported in combinations. In the 15 4-AcO-DiPT reports where another drug was taken too, 4 mention hospital, emergency services or an overdose, 1 a seizure and 0 psychosis (too few reports for percentages). In the 32 single-substance reports: 9.4%, 0.0% and 0.0%. These are not in the figures above: they cannot be put down to 4-AcO-DiPT alone, and a mention is not always something that happened to the writer.

    Dose-Response Correlation

    How effect frequency changes across dose levels. Whiskers, and the numbers' hover text, give each figure's 95% interval.

    Not drawn, too few reports (a dose tier needs 20): Oral Strong (n=16). Why 20?

    Dosage Distribution

    Dose distribution from experience reports, one dose per report (the first listed). Doses above Q3 + 3×IQR, far above what people typically take, are left out of the median and range and listed under each route: most are real heavy doses or overdoses, not mistakes.

    Median: 25.0 mg IQR: 20.0–31.0 mg n=35

    Real-World Dose Distribution

    Erowid

    From 70 of 74 recorded dose entries: those that state a weight (mg, g or µg), in routes with at least five of them. Values above Q3 + 3×IQR, far above what people typically take, are left out; they can include real heavy doses and overdoses, not only mistakes.

    Oral (n=69)

    Median: 20.0mg 25th: 17.0mg 75th: 30.0mg 90th: 37.6mg

    Common Combinations

    Most co-occurring substances, as a share of all 47 reports filed under 4-AcO-DiPT; whiskers are 95% intervals

    Form / Preparation

    Most common forms and preparations, as a share of the 39 reports that give one; whiskers are 95% intervals

    Body-Weight Dosing

    Dose per kg of body weight, one dose per report (the first listed), from reports giving a weight of 30–250 kg. Doses above Q3 + 3×IQR, far above what people typically take, are left out of the median and range and listed under each route.

    Median: 0.362 mg/kg IQR: 0.269–0.426 mg/kg n=34

    Redose Patterns

    Redosing behavior across 39 reports

    25.6% (95% interval 15 to 41 percent) Redosed
    1.4 Avg Doses
    150m Median Interval

    Legal Status

    Country Status Notes
    Denmark Schedule B Listed as a Schedule B controlled substance under Danish drug control legislation.
    Finland Controlled substance Banned in December 2014 under a government regulation that prohibited over 100 psychoactive chemicals.
    Germany Controlled (NpSG) Controlled under the Neue-psychoaktive-Stoffe-Gesetz (New Psychoactive Substances Act) as of July 18, 2019. Production, import with intent to distribute, administration to others, and trading are punishable offenses. Possession is illegal but not subject to criminal penalties.
    Japan Designated Substance (Shitei-Yakubutsu) Controlled under the Pharmaceutical Affairs Law, making both possession and sale illegal.
    Sweden Illegal Classified as a health hazard under the Act on the Prohibition of Certain Goods Dangerous to Health (Lagen om förbud mot vissa hälsofarliga varor) as of March 1, 2005, in regulation SFS 2005:26. Both possession and sale are prohibited.
    Switzerland Controlled (Verzeichnis E) Specifically named as a controlled substance under Verzeichnis E of Swiss narcotics legislation.
    United Kingdom Class A Controlled under the Misuse of Drugs Act 1971. This classification applies because 4-AcO-DiPT is an ester of 4-HO-DiPT, which is controlled under the tryptamine catch-all clause.
    United States Unscheduled Not scheduled under the Controlled Substances Act. However, due to structural similarities to scheduled tryptamines such as psilocin, possession and sale for human consumption may be prosecuted under the Federal Analogue Act. Pending cases have existed since July 2004 involving vendors selling this substance, though no convictions have established further legal precedent.
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