4-AcO-DiPT Stats & Data
CC(=O)Oc1cccc2ncc(CCN(C(C)C)C(C)C)c12ZPAOVGZYDSXCPK-UHFFFAOYSA-NReceptor Profile
Receptor Actions
History & Culture
4-AcO-DiPT was first characterized in the scientific literature by Alexander Shulgin, with documentation appearing by 2003. The compound is described in TiHKAL (Tryptamines I Have Known and Loved), Shulgin's comprehensive reference work on tryptamine compounds co-authored with Ann Shulgin. The substance represents one of the early psychedelic research chemicals that emerged following Shulgin's initial synthesis and documentation, predating the widespread proliferation of online research chemical vendors that would later characterize the early 2000s market. It was first identified as a novel designer drug in 2005, marking its appearance in recreational and research contexts outside of Shulgin's laboratory work.
Subjective Effects
Physical
- Bodily control enhancement
- Increased heart rate
- Nausea
- Pupil dilation
- Spontaneous tactile sensations
- Tactile enhancement
Cognitive
- Analysis enhancement
- Conceptual thinking
- Creativity enhancement
- Delusions
- Emotion enhancement
- Immersion enhancement
- Memory suppression
- Mindfulness
- Novelty enhancement
- Personal bias suppression
- Spirituality enhancement
- Thought acceleration
- Thought disorganization
- Thought loops
- Time distortion
- Unity and interconnectedness
- Wakefulness
- Ego death
Sensory
- Enhancements
- Distortions
- Hallucinations
- Drifting: (melting, breathing, morphing and flowing)
- Colour shifting
- Depth perception distortions
- Perspective distortions
- Symmetrical texture repetition
- Tracers
- Colour enhancement
- Pattern recognition enhancement
- Visual acuity enhancement
- Transformations
- Internal hallucinations: (autonomous entities; settings, sceneries, and landscapes; alterations in perspective and scenarios and plots)
Forked from Subjective Effect Documentation work by Josie Kins, August 2016. Via dose.wiki (CC0).
Toxicity
PsychonautWikiThe toxicity and long-term health effects of recreational 4-AcO-DiPT use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because 4-AcO-DiPT is a research chemical with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried 4-AcO-DiPT suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (although nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption. It is strongly recommended that one use harm reduction practices when using this drug.
Effect Profile
Curated + 32 ReportsStrong visuals and auditory effects with strong body load, moderate headspace
Tolerance & Pharmacokinetics
drugs.wikiTolerance Decay
Cross-Tolerances
Experience Report Analysis
ErowidDemographics
Gender Distribution
Age Distribution
Reports Over Time
Effect Analysis
ErowidEffects aggregated from 32 experience reports (32 single-substance Erowid)
Effect Sentiment Distribution
Confidence Distribution
Each bar is the share of reports mentioning the effect; its whisker, and the band on the rows below, is the 95% interval: where the share could plausibly be with other reports of the same kind.
Positive Effects 12
Adverse Effects 7
Show 5 neutral or unclassified mentions
Also reported in combinations. In the 15 4-AcO-DiPT reports where another drug was taken too, 4 mention hospital, emergency services or an overdose, 1 a seizure and 0 psychosis (too few reports for percentages). In the 32 single-substance reports: 9.4%, 0.0% and 0.0%. These are not in the figures above: they cannot be put down to 4-AcO-DiPT alone, and a mention is not always something that happened to the writer.
Dose-Response Correlation
How effect frequency changes across dose levels. Whiskers, and the numbers' hover text, give each figure's 95% interval.
Not drawn, too few reports (a dose tier needs 20): Oral Strong (n=16). Why 20?
Dosage Distribution
Dose distribution from experience reports, one dose per report (the first listed). Doses above Q3 + 3×IQR, far above what people typically take, are left out of the median and range and listed under each route: most are real heavy doses or overdoses, not mistakes.
Real-World Dose Distribution
ErowidFrom 70 of 74 recorded dose entries: those that state a weight (mg, g or µg), in routes with at least five of them. Values above Q3 + 3×IQR, far above what people typically take, are left out; they can include real heavy doses and overdoses, not only mistakes.
Oral (n=69)
Common Combinations
Most co-occurring substances, as a share of all 47 reports filed under 4-AcO-DiPT; whiskers are 95% intervals
Form / Preparation
Most common forms and preparations, as a share of the 39 reports that give one; whiskers are 95% intervals
Body-Weight Dosing
Dose per kg of body weight, one dose per report (the first listed), from reports giving a weight of 30–250 kg. Doses above Q3 + 3×IQR, far above what people typically take, are left out of the median and range and listed under each route.
Redose Patterns
Redosing behavior across 39 reports
Legal Status
| Country | Status | Notes |
|---|---|---|
| Denmark | Schedule B | Listed as a Schedule B controlled substance under Danish drug control legislation. |
| Finland | Controlled substance | Banned in December 2014 under a government regulation that prohibited over 100 psychoactive chemicals. |
| Germany | Controlled (NpSG) | Controlled under the Neue-psychoaktive-Stoffe-Gesetz (New Psychoactive Substances Act) as of July 18, 2019. Production, import with intent to distribute, administration to others, and trading are punishable offenses. Possession is illegal but not subject to criminal penalties. |
| Japan | Designated Substance (Shitei-Yakubutsu) | Controlled under the Pharmaceutical Affairs Law, making both possession and sale illegal. |
| Sweden | Illegal | Classified as a health hazard under the Act on the Prohibition of Certain Goods Dangerous to Health (Lagen om förbud mot vissa hälsofarliga varor) as of March 1, 2005, in regulation SFS 2005:26. Both possession and sale are prohibited. |
| Switzerland | Controlled (Verzeichnis E) | Specifically named as a controlled substance under Verzeichnis E of Swiss narcotics legislation. |
| United Kingdom | Class A | Controlled under the Misuse of Drugs Act 1971. This classification applies because 4-AcO-DiPT is an ester of 4-HO-DiPT, which is controlled under the tryptamine catch-all clause. |
| United States | Unscheduled | Not scheduled under the Controlled Substances Act. However, due to structural similarities to scheduled tryptamines such as psilocin, possession and sale for human consumption may be prosecuted under the Federal Analogue Act. Pending cases have existed since July 2004 involving vendors selling this substance, though no convictions have established further legal precedent. |
References
Cited References
- Bluelight: 4-AcO-DiPT Discussion Thread
- Erowid: 4-Acetoxy-DiPT Primer by Toad
- Human Hepatocyte 4-AcO-DiPT Metabolite Profiling Study
- Investigation of Structure-Activity Relationships of Psilocybin Analogues
- Isomer Design: 4-AcO-DiPT
- Pharmacologic Activity of Substituted Tryptamines Study
- TiHKAL Entry #17: 4-HO-DiPT