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    2C-I molecular structure

    2C-I Stats & Data

    2ci
    PubChem
    MW307.13
    FormulaC10H14INO2
    LogP1.8
    IUPAC2-(4-iodo-2,5-dimethoxyphenyl)ethanamine
    SMILESCOC1=CC(=C(C=C1CCN)OC)I
    InChIKeyPQHQBRJAAZQXHL-UHFFFAOYSA-N
    Chemical Class 2C-x phenethylamine
    Psychoactive Class Psychedelic

    Pharmacology

    DrugBank

    Description

    2C-I is a lesser known psychedelic of the substituted phenethylamine class. In the early 2000s, 2C-I was sold in Dutch smart shops after the drug 2C-B was banned.

    Receptor Profile

    Receptor Actions

    Agonists
    5-HT2A receptor agonist (partial)
    5-HT2B receptor agonist
    5-HT2C receptor agonist

    History & Culture

    1976–1991

    2C-I was first synthesized and investigated for human activity by Alexander Shulgin in the mid-to-late 1970s. The compound was initially described in scientific literature in 1977, with its properties and effects in humans documented the following year. Shulgin later provided a more comprehensive account of his research with 2C-I in his 1991 book PiHKAL (Phenethylamines I Have Known and Loved), which brought the substance to wider public awareness within psychedelic research communities. The presence of a heavy iodine atom in the molecule made 2C-I particularly suitable for radio-labeling experiments. The compound has been synthesized with radioactive iodine for research purposes, though more extensive radiological findings have emerged from studies using its three-carbon amphetamine analog, DOI.

    1995–2004

    2C-I began to emerge as a recreational substance in the late 1990s, initially gaining popularity in Dutch smart shops where it was sold as a legal alternative to 2C-B following that compound's scheduling in 1995. The substance became more widely available through grey market online vendors around 2002, marketed as a "research chemical" alongside other novel psychoactive substances. Distribution significantly declined after a series of DEA enforcement actions in 2004 that targeted vendors selling research chemicals intended for human consumption. Throughout its period of availability, 2C-I was sometimes confused with the structurally related but considerably more potent compound 25I-NBOMe, which media outlets subsequently nicknamed "Smiles." This confusion has contributed to ongoing concerns about accurate identification and appropriate harm reduction information for users.

    Subjective Effects

    Physical
    • Spontaneous tactile sensations: The body high of 2C-I is manifested as one of the most proportionally intense in comparison to almost all of the classical psychedelics. The sensation itself can be described as an intense and slightly uncomfortable energetic pins and needles sensation that constantly encompasses a person's entire body. It is usually felt over every square inch of the skin but occasionally manifests itself in the form of a continuously shifting tingling sensation that travels up and down the body in spontaneous waves. Alongside of this, many users commonly report that the body high can be particularly uncomfortable and sometimes accompanied by dysphoric aches and urges to shift the position of one's body and prolonged tensing of unusual combinations of muscle groups.
    • Physical euphoria: Feelings of frequent but unpredictable rushes of warm physical euphoria are extremely common and very pleasurable. These move from the top of the head downwards before enveloping one's whole body.
    • Stimulation: In terms of its effects on the physical energy levels of the tripper, 2C-I is usually considered to be very energetic and stimulating in a fashion that is quite comparable to that of MDMA although encouraged instead of forced.
    • Increased bodily control
    • Tactile enhancement
    • Nausea: Mild to extreme nausea is consistently reported when consumed in moderate to high dosages and either passes once the tripper has vomited or gradually fades by itself as the peak sets in.
    • Temperature regulation loss
    • Headaches: Some users report mild but uncomfortable head pressures which can occasionally intensify during the offset of the experience.
    Cognitive

    The head space of 2C-I is described by many as one which is relatively normal in its thought processes even at moderate to high dosages. It is often said to lack insight when compared to that of 2C-E, 2C-B and LSD.

    • Empathy, love and sociability enhancement: This component is consistently manifested only in the context of social settings in which one is within the company of others. These feelings of sociability, love and empathy are a little weaker and less sharp than those found on substances such as MDMA and 2C-B but still prove strong enough to provide long lasting therapeutic effects.
    • Time distortion
    • Feelings of fascination, importance and awe
    • Sexual arousal
    • Current mind state enhancement
    • Ego suppression, loss and death
    • Unity and interconnectedness
    Sensory
    Auditory
    • Enhancements
    • Distortions
    • Hallucinations
    Visual · Distortions
    • Visual drifting: (Melting, Flowing, Breathing and Morphing) - In comparison to other psychedelics, this effect can be described as simplistic and bland in detail, slow and smooth but sometimes jittery in motion, static in appearance and unrealistic/cartoon-like in style.
    • Tracers
    • Symmetrical texture repetition: In comparison to other psychedelics such as LSD and 2C-E this particular effect is bland and simplistic.
    • Colour shifting
    • Scenery slicing
    Visual · Enhancements
    • Increased visual acuity
    • Enhancement of colour
    • Enhanced pattern recognition
    Visual · Hallucinatory States

    Like LSD, while 2C-I is capable of producing a full range of low and high level hallucinatory states, this is extremely rare and inconsistent at higher levels but common at lower levels.

    • External hallucinations: The experience of effects such as open eye transformations are common within 2C-I but not consistent.
    • Internal hallucinations: Although 2C-I is technically capable of producing hallucinatory states in a fashion that is on par with psilocin or DMT in its vividness and intensity, in comparison, these effects are extremely rare and inconsistent. Whilst traditional psychedelics such as LSA, ayahuasca and mescaline will induce internal hallucinations near consistently at level 5 geometry and above, 2C-I hallucinations will not extend beyond imagery and higher dosages will for most simply go straight into Level 7A visual geometry. This lack of consistently induced hallucinatory breakthroughs means that for most, 2C-I is simply not as deep of an experience as certain other psychedelics.

    Forked from Subjective Effect Documentation by Josie Kins, March 2014. Via dose.wiki (CC0).

    Toxicity

    PsychonautWiki

    The toxicity and long-term health effects of recreational 2C-I use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because 2C-I is a research chemical with very little history of human usage. Anecdotal reports from those who have tried 2C-I suggests that there are no negative health effects attributed to simply trying the substance by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption. It is strongly recommended that one use harm reduction practices, such as volumetric dosing, when using this substance so as to ensure the accurate administration of the intended dose.

    Effect Profile

    Curated + 414 Reports
    Psychedelic 8.4

    Strong visuals, auditory effects, and headspace with strong body load

    Visual Intensity×3
    10103.8
    Headspace Depth×3
    98.42.4
    Auditory Effects×1
    10101.0
    Body Load / Somatic Effects×1
    108.62.8
    Catalog Erowid BlueLight

    Duration Timeline

    Bluelight
    Onset Comeup Peak Offset After Effects
    Insufflated
    45 minutes - 2.0 hours
    4.0-8.0 hours
    4.0-12.0 hours
    Oral
    12-48 minutes
    48 minutes - 1.5 hours
    3-5 hours
    2-3 hours
    6-24 hours
    Total: 5-10 hours

    Empirical Duration

    Erowid Reports

    Median times after the dose that Erowid reports state. A curve is drawn only when reports state all four points (onset, peak begins, comedown begins, back to baseline) and the medians fall in that order. No point is estimated from another.

    Onset Come Up Peak Offset
    Oral (82 reports)

    Community Effects

    TripSit
    Positive
    visual enhancement euphoria stimulation color enhancement
    Negative
    nausea body load vasoconstriction

    Tolerance & Pharmacokinetics

    drugs.wiki
    Half-Life
    Unknown in humans; subjective effect window consistent with several hours of action (often cited ~4–6 h), but no formal human PK published.
    Addiction Potential
    Low; 2C-I is not considered physically addictive, though psychological habituation is possible with frequent use.

    Tolerance Decay

    Half tolerance 5d Baseline ~10d

    Subjective tolerance to classical psychedelics rises acutely and tends to decrease substantially over 3–7 days and return near baseline by 1–2 weeks; cross‑tolerance across serotonergic psychedelics is common, though exact ratios are not quantified.

    Experience Report Analysis

    Erowid BlueLight
    508 Reports
    272 Single-substance
    2000–2025 Date Range
    124 With Age Data
    32 Effects Detected

    Demographics

    Gender Distribution

    Age Distribution

    Reports Over Time

    Effect Analysis

    Erowid + Bluelight

    Effects aggregated from 322 experience reports (272 single-substance Erowid + 142 Bluelight)

    322 Reports
    157 Effects Detected
    77 Positive
    45 Adverse
    35 Neutral

    Effect Sentiment Distribution

    Confidence Distribution

    Each bar is the share of reports mentioning the effect; its whisker, and the band on the rows below, is the 95% interval: where the share could plausibly be with other reports of the same kind.

    Positive Effects 77

    Visual Distortions 68.9% (95% interval 64 to 74 percent) 79%
    Stimulation 51.2% (95% interval 46 to 57 percent) 86%
    Color Enhancement 49.3% (95% interval 44 to 55 percent) 87%
    Surface Breathing 48.0% (95% interval 35 to 62 percent) 86%
    Music Enhancement 43.8% (95% interval 38 to 49 percent) 90%
    Euphoria 39.1% (95% interval 34 to 45 percent) 88%
    Awe 38.0% (95% interval 26 to 52 percent) 84%
    Visual Trails 36.0% (95% interval 24 to 50 percent) 87%
    Empathy 34.4% (95% interval 30 to 40 percent) 82%
    Joy 28.0% (95% interval 18 to 42 percent) 88%
    Introspection 25.7% (95% interval 21 to 31 percent) 85%
    Insight 24.0% (95% interval 14 to 37 percent) 84%
    Closed-Eye Visuals 23.6% (95% interval 19 to 28 percent) 93%
    Patterning 22.0% (95% interval 13 to 35 percent) 86%
    Morphing 22.0% (95% interval 13 to 35 percent) 87%
    Melting/flowing 22.0% (95% interval 13 to 35 percent) 87%
    Body High 21.7% (95% interval 18 to 27 percent) 85%
    Geometric Imagery 20.0% (95% interval 11 to 33 percent) 86%
    Warping 18.0% (95% interval 10 to 31 percent) 86%
    Sociability Enhancement 18.0% (95% interval 10 to 31 percent) 84%

    Adverse Effects 45

    Anxiety 40.0% (95% interval 35 to 46 percent) 86%
    Nausea 26.4% (95% interval 22 to 32 percent) 85%
    Confusion 22.9% (95% interval 19 to 28 percent) 85%
    Body Load 22.0% (95% interval 13 to 35 percent) 84%
    Tremor 16.0% (95% interval 8 to 28 percent) 83%
    Muscle Tension 13.0% (95% interval 10 to 17 percent) 81%
    Pupil Dilation 13.0% (95% interval 10 to 17 percent) 84%
    Restlessness 12.0% (95% interval 6 to 24 percent) 83%
    Paranoia 12.0% (95% interval 6 to 24 percent) 75%
    Jaw Clenching 10.9% (95% interval 8 to 15 percent) 85%
    Headache 8.4% (95% interval 6 to 12 percent) 68%
    Fear 8.0% (95% interval 3 to 19 percent) 89%
    Depersonalization 8.0% (95% interval 3 to 19 percent) 81%
    Stomach Cramps 6.0% (95% interval 2 to 16 percent) 80%
    Panic 6.0% (95% interval 2 to 16 percent) 84%
    Sweating 5.9% (95% interval 4 to 9 percent) 84%
    Motor Impairment 5.6% (95% interval 4 to 9 percent) 75%
    Increased Heart Rate 5.5% (95% interval 3 to 9 percent) 70%
    Thought Loops 4.6% (95% interval 3 to 8 percent) 80%
    Memory Suppression 4.3% (95% interval 3 to 7 percent) 77%
    ⚠ Psychosis 2.2% (95% interval 1 to 5 percent) 70%
    ⚠ Chest Pain 2.0% (95% interval 0 to 10 percent) 95%
    Show 23 more adverse effects
    Social Anxiety 4.0% (95% interval 1 to 14 percent) 85%
    Dizziness 4.0% (95% interval 1 to 14 percent) 80%
    Vertigo 4.0% (95% interval 1 to 14 percent) 82%
    Tachycardia 4.0% (95% interval 1 to 14 percent) 85%
    Restless Legs 4.0% (95% interval 1 to 14 percent) 80%
    Ataxia 4.0% (95% interval 1 to 14 percent) 82%
    Vomiting 4.0% (95% interval 1 to 14 percent) 90%
    Body Anxiety 2.0% (95% interval 0 to 10 percent) 80%
    Shortness Of Breath 2.0% (95% interval 0 to 10 percent) 85%
    Muscle Spasm 2.0% (95% interval 0 to 10 percent) 70%
    Emotional Blunting 2.0% (95% interval 0 to 10 percent) 65%
    Dysphoria 2.0% (95% interval 0 to 10 percent) 90%
    Taste Distortion 2.0% (95% interval 0 to 10 percent) 95%
    Appetite Suppression 2.0% (95% interval 0 to 10 percent) 85%
    Delusion 2.0% (95% interval 0 to 10 percent) 75%
    Symbolic Imagery 2.0% (95% interval 0 to 10 percent) 85%
    Chest Tightness 2.0% (95% interval 0 to 10 percent) 75%
    Congestion 2.0% (95% interval 0 to 10 percent) 65%
    Crying 2.0% (95% interval 0 to 10 percent) 90%
    Pain Enhancement 2.0% (95% interval 0 to 10 percent) 80%
    Emotional Instability 2.0% (95% interval 0 to 10 percent) 85%
    Visual Snow 2.0% (95% interval 0 to 10 percent) 80%
    Sadness 2.0% (95% interval 0 to 10 percent) 85%
    Show 35 neutral or unclassified mentions
    Thought Acceleration 30.0% (95% interval 19 to 44 percent)
    Time Dilation 26.0% (95% interval 16 to 40 percent)
    Sedation 25.4% (95% interval 21 to 31 percent)
    Thought Disorganization 18.0% (95% interval 10 to 31 percent)
    Auditory Effects 17.7% (95% interval 14 to 22 percent)
    Entity Imagery 16.0% (95% interval 8 to 28 percent)
    Dissociation 12.7% (95% interval 10 to 17 percent)
    Ego Dissolution 9.9% (95% interval 7 to 14 percent)
    Time Distortion 9.6% (95% interval 7 to 14 percent)
    Chills 8.0% (95% interval 3 to 19 percent)
    Time Disorientation 8.0% (95% interval 3 to 19 percent)
    Contact-With-Presence 6.0% (95% interval 2 to 16 percent)
    Hospital 5.1% (95% interval 3 to 8 percent)
    Vibrating 4.0% (95% interval 1 to 14 percent)
    Visual Clarity 4.0% (95% interval 1 to 14 percent)
    Shadow Imagery 4.0% (95% interval 1 to 14 percent)
    Size Distortion 4.0% (95% interval 1 to 14 percent)
    Thought Deceleration 4.0% (95% interval 1 to 14 percent)
    Revelatory Insight 4.0% (95% interval 1 to 14 percent)
    Frequent Urination 4.0% (95% interval 1 to 14 percent)
    Fish-Eye Distortion 2.0% (95% interval 0 to 10 percent)
    Focus Suppression 2.0% (95% interval 0 to 10 percent)
    Perspective Distortion 2.0% (95% interval 0 to 10 percent)
    Metallic Taste 2.0% (95% interval 0 to 10 percent)
    No Nausea 2.0% (95% interval 0 to 10 percent)
    Salivation 2.0% (95% interval 0 to 10 percent)
    Distractibility 2.0% (95% interval 0 to 10 percent)
    Pattern Recognition Enhancement 2.0% (95% interval 0 to 10 percent)
    Body Temperature Change 2.0% (95% interval 0 to 10 percent)
    Directional Hearing Distortion 2.0% (95% interval 0 to 10 percent)
    Temporal Disorientation 2.0% (95% interval 0 to 10 percent)
    Pressure 2.0% (95% interval 0 to 10 percent)
    Numbness 2.0% (95% interval 0 to 10 percent)
    Tension 2.0% (95% interval 0 to 10 percent)
    Blurred Vision 2.0% (95% interval 0 to 10 percent)

    Also reported in combinations. In the 236 2C-I reports where another drug was taken too, 22 (9.3%) mention hospital, emergency services or an overdose, 1 (0.4%) a seizure and 10 (4.2%) psychosis. In the 272 single-substance reports: 5.1%, 0.7% and 2.2%. These are not in the figures above: they cannot be put down to 2C-I alone, and a mention is not always something that happened to the writer.

    Dose-Response Correlation

    How effect frequency changes across dose levels. Whiskers, and the numbers' hover text, give each figure's 95% interval.

    Not drawn, too few reports (a dose tier needs 20): Oral Light (n=11), Oral Heavy (n=15). Why 20?

    View data table
    Effect Common (n=56) Strong (n=56)
    Visual Distortions 85.7% (95% interval 74 to 93 percent) 89.3% (95% interval 78 to 95 percent)
    Stimulation 69.6% (95% interval 57 to 80 percent) 48.2% (95% interval 36 to 61 percent)
    Color Enhancement 53.6% (95% interval 41 to 66 percent) 66.1% (95% interval 53 to 77 percent)
    Music Enhancement 50.0% (95% interval 37 to 63 percent) 53.6% (95% interval 41 to 66 percent)
    Euphoria 48.2% (95% interval 36 to 61 percent) 46.4% (95% interval 34 to 59 percent)
    Empathy 39.3% (95% interval 28 to 52 percent) 48.2% (95% interval 36 to 61 percent)
    Anxiety 37.5% (95% interval 26 to 51 percent) 44.6% (95% interval 32 to 58 percent)
    Sedation 30.4% (95% interval 20 to 43 percent) 39.3% (95% interval 28 to 52 percent)
    Confusion 28.6% (95% interval 18 to 42 percent) 39.3% (95% interval 28 to 52 percent)
    Closed-Eye Visuals 26.8% (95% interval 17 to 40 percent) 28.6% (95% interval 18 to 42 percent)
    Nausea 26.8% (95% interval 17 to 40 percent) 23.2% (95% interval 14 to 36 percent)
    Introspection 26.8% (95% interval 17 to 40 percent) 26.8% (95% interval 17 to 40 percent)
    Auditory Effects 25.0% (95% interval 16 to 38 percent) 21.4% (95% interval 13 to 34 percent)
    Open-Eye Visuals 5.4% (95% interval 2 to 15 percent) 23.2% (95% interval 14 to 36 percent)
    Tactile Enhancement 12.5% (95% interval 6 to 24 percent) 21.4% (95% interval 13 to 34 percent)

    Subjective Effect Ontology

    Experience Reports

    Structured effect tags extracted from 558 Erowid & Bluelight experience reports using a controlled vocabulary of 220+ canonical effects across 15 domains.

    Auditory

    music enhancement 254 45.5% (95% interval 41 to 50 percent)

    Cognitive

    confusion 169 30.3% (95% interval 27 to 34 percent) introspection 156 28.0% (95% interval 24 to 32 percent) focus enhancement 144 25.8% (95% interval 22 to 30 percent)

    Emotional

    anxiety 244 43.8% (95% interval 40 to 48 percent) euphoria 235 42.1% (95% interval 38 to 46 percent) empathy 206 36.9% (95% interval 33 to 41 percent)

    Gastrointestinal

    nausea 166 29.7% (95% interval 26 to 34 percent)

    Motor

    stimulation 283 50.7% (95% interval 47 to 55 percent) sedation 149 29.3% (95% interval 26 to 33 percent)

    Somatic

    body high 136 24.4% (95% interval 21 to 28 percent)

    Tactile

    tactile enhancement 170 30.5% (95% interval 27 to 34 percent)

    Visual

    visual distortions 432 77.5% (95% interval 74 to 81 percent) color enhancement 300 53.7% (95% interval 50 to 58 percent) closed eye visuals 138 24.7% (95% interval 21 to 28 percent) open eye visuals 103 18.5% (95% interval 16 to 22 percent)

    16 unique effects extracted · Derived from Erowid & Bluelight reports

    Dose–Effect Mapping

    Experience Reports

    How reported effects shift across dose tiers, based on 272 single-substance experience reports. The shaded band on each bar is its 95% interval. An arrow (↑ ↓) marks a change between the lowest and highest tier that count an effect only when the gap is bigger than chance would explain; ~ means no clear change. How changes are called

    Not drawn, too few reports (a dose tier needs 20): Oral Light (n=11), Oral Heavy (n=15). Why 20?

    Limited tier coverage — most reports fall within the Common / Strong range. Effects at other dose levels may not be represented.

    Oral dose range: 15.0–20.0 mg (median 20.0 mg)
    Effect Common (n=56) Strong (n=56) Change with dose
    visual distortions
    86% (95% interval 74 to 93 percent)
    89% (95% interval 78 to 95 percent)
    (no clear change: +4 points from Common to Strong, 95% interval −9 to +16)
    stimulation
    70% (95% interval 57 to 80 percent)
    48% (95% interval 36 to 61 percent)
    (−21 points from Common to Strong, 95% interval −38 to −3)
    color enhancement
    54% (95% interval 41 to 66 percent)
    66% (95% interval 53 to 77 percent)
    (no clear change: +12 points from Common to Strong, 95% interval −6 to +29)
    music enhancement
    50% (95% interval 37 to 63 percent)
    54% (95% interval 41 to 66 percent)
    (no clear change: +4 points from Common to Strong, 95% interval −14 to +21)
    euphoria
    48% (95% interval 36 to 61 percent)
    46% (95% interval 34 to 59 percent)
    (no clear change: −2 points from Common to Strong, 95% interval −20 to +16)
    empathy
    39% (95% interval 28 to 52 percent)
    48% (95% interval 36 to 61 percent)
    (no clear change: +9 points from Common to Strong, 95% interval −9 to +26)
    anxiety
    38% (95% interval 26 to 51 percent)
    45% (95% interval 32 to 58 percent)
    (no clear change: +7 points from Common to Strong, 95% interval −11 to +24)
    sedation
    30% (95% interval 20 to 43 percent)
    39% (95% interval 28 to 52 percent)
    (no clear change: +9 points from Common to Strong, 95% interval −8 to +26)
    confusion
    29% (95% interval 18 to 42 percent)
    39% (95% interval 28 to 52 percent)
    (no clear change: +11 points from Common to Strong, 95% interval −7 to +27)
    closed-eye visuals
    27% (95% interval 17 to 40 percent)
    29% (95% interval 18 to 42 percent)
    (no clear change: +2 points from Common to Strong, 95% interval −15 to +18)
    nausea
    27% (95% interval 17 to 40 percent)
    23% (95% interval 14 to 36 percent)
    (no clear change: −4 points from Common to Strong, 95% interval −19 to +12)
    introspection
    27% (95% interval 17 to 40 percent)
    27% (95% interval 17 to 40 percent)
    (no clear change: 0 points from Common to Strong, 95% interval −16 to +16)
    auditory effects
    25% (95% interval 16 to 38 percent)
    21% (95% interval 13 to 34 percent)
    (no clear change: −4 points from Common to Strong, 95% interval −19 to +12)
    open-eye visuals
    5% (95% interval 2 to 15 percent)
    23% (95% interval 14 to 36 percent)
    (+18 points from Common to Strong, 95% interval +5 to +31)
    tactile enhancement
    12% (95% interval 6 to 24 percent)
    21% (95% interval 13 to 34 percent)
    (no clear change: +9 points from Common to Strong, 95% interval −5 to +23)
    body high
    16% (95% interval 9 to 28 percent)
    20% (95% interval 11 to 32 percent)
    (no clear change: +4 points from Common to Strong, 95% interval −11 to +18)
    dissociation
    18% (95% interval 10 to 30 percent)
    12% (95% interval 6 to 24 percent)
    (no clear change: −5 points from Common to Strong, 95% interval −19 to +8)
    muscle tension
    18% (95% interval 10 to 30 percent)
    16% (95% interval 9 to 28 percent)
    (no clear change: −2 points from Common to Strong, 95% interval −16 to +12)
    pupil dilation
    11% (95% interval 5 to 22 percent)
    16% (95% interval 9 to 28 percent)
    (no clear change: +5 points from Common to Strong, 95% interval −8 to +18)
    ego dissolution
    14% (95% interval 7 to 26 percent)
    14% (95% interval 7 to 26 percent)
    (no clear change: 0 points from Common to Strong, 95% interval −13 to +13)

    Showing top 20 of 32 effects

    Risk Escalation

    Sentiment Analysis

    Average frequency of positive vs adverse effects across dose tiers. A tier's average is the mean share of the effects counted in that tier, not a share of reports, and its range is a deliberately wide 95% interval. A tier with more reports also counts rarer effects, which pulls its average down, so compare single effects in the breakdown rather than these averages. There, the shaded band on each bar is its 95% interval, and Change is marked up or down only when the gap between two tiers is bigger than chance would explain. How changes are called

    Not drawn, too few reports (a dose tier needs 20): Light (n=11), Heavy (n=15). Why 20?

    Common n=56
    13 positive 34.8% (95% interval 25 to 46 percent) 12 adverse 13.7% (95% interval 8 to 24 percent)
    Strong n=56
    13 positive 37.8% (95% interval 28 to 49 percent) 11 adverse 16.9% (95% interval 10 to 28 percent)
    View effect breakdown

    Adverse Effects

    Effect Common (n=56) Strong (n=56) Change
    Anxiety
    38% (95% interval 26 to 51 percent)
    45% (95% interval 32 to 58 percent)
    no clear change (no clear change: +7 points from Common to Strong, 95% interval −11 to +24)
    Confusion
    29% (95% interval 18 to 42 percent)
    39% (95% interval 28 to 52 percent)
    no clear change (no clear change: +11 points from Common to Strong, 95% interval −7 to +27)
    Nausea
    27% (95% interval 17 to 40 percent)
    23% (95% interval 14 to 36 percent)
    no clear change (no clear change: −4 points from Common to Strong, 95% interval −19 to +12)
    Muscle Tension
    18% (95% interval 10 to 30 percent)
    16% (95% interval 9 to 28 percent)
    no clear change (no clear change: −2 points from Common to Strong, 95% interval −16 to +12)
    Pupil Dilation
    11% (95% interval 5 to 22 percent)
    16% (95% interval 9 to 28 percent)
    no clear change (no clear change: +5 points from Common to Strong, 95% interval −8 to +18)
    Jaw Clenching
    11% (95% interval 5 to 22 percent)
    9% (95% interval 4 to 19 percent)
    no clear change (no clear change: −2 points from Common to Strong, 95% interval −14 to +10)
    Headache
    7% (95% interval 3 to 17 percent)
    11% (95% interval 5 to 22 percent)
    no clear change (no clear change: +4 points from Common to Strong, 95% interval −8 to +15)
    Motor Impairment
    9% (95% interval 4 to 19 percent)
    7% (95% interval 3 to 17 percent)
    no clear change (no clear change: −2 points from Common to Strong, 95% interval −13 to +9)
    Memory Suppression
    4% (95% interval 1 to 12 percent)
    9% (95% interval 4 to 19 percent)
    no clear change (no clear change: +5 points from Common to Strong, 95% interval −5 to +16)
    Thought Loops —
    7% (95% interval 3 to 17 percent)
    —
    Appetite Suppression
    5% (95% interval 2 to 15 percent)
    — —
    Sweating
    4% (95% interval 1 to 12 percent)
    — —
    Increased Heart Rate
    4% (95% interval 1 to 12 percent)
    4% (95% interval 1 to 12 percent)
    no clear change (no clear change: 0 points from Common to Strong, 95% interval −9 to +9)

    Positive Effects

    Effect Common (n=56) Strong (n=56) Change
    Visual Distortions
    86% (95% interval 74 to 93 percent)
    89% (95% interval 78 to 95 percent)
    no clear change (no clear change: +4 points from Common to Strong, 95% interval −9 to +16)
    Stimulation
    70% (95% interval 57 to 80 percent)
    48% (95% interval 36 to 61 percent)
    −21 pts (−21 points from Common to Strong, 95% interval −38 to −3)
    Color Enhancement
    54% (95% interval 41 to 66 percent)
    66% (95% interval 53 to 77 percent)
    no clear change (no clear change: +12 points from Common to Strong, 95% interval −6 to +29)
    Music Enhancement
    50% (95% interval 37 to 63 percent)
    54% (95% interval 41 to 66 percent)
    no clear change (no clear change: +4 points from Common to Strong, 95% interval −14 to +21)
    Euphoria
    48% (95% interval 36 to 61 percent)
    46% (95% interval 34 to 59 percent)
    no clear change (no clear change: −2 points from Common to Strong, 95% interval −20 to +16)
    Empathy
    39% (95% interval 28 to 52 percent)
    48% (95% interval 36 to 61 percent)
    no clear change (no clear change: +9 points from Common to Strong, 95% interval −9 to +26)
    Closed-Eye Visuals
    27% (95% interval 17 to 40 percent)
    29% (95% interval 18 to 42 percent)
    no clear change (no clear change: +2 points from Common to Strong, 95% interval −15 to +18)
    Introspection
    27% (95% interval 17 to 40 percent)
    27% (95% interval 17 to 40 percent)
    no clear change (no clear change: 0 points from Common to Strong, 95% interval −16 to +16)
    Open-Eye Visuals
    5% (95% interval 2 to 15 percent)
    23% (95% interval 14 to 36 percent)
    +18 pts (+18 points from Common to Strong, 95% interval +5 to +31)
    Tactile Enhancement
    12% (95% interval 6 to 24 percent)
    21% (95% interval 13 to 34 percent)
    no clear change (no clear change: +9 points from Common to Strong, 95% interval −5 to +23)
    Body High
    16% (95% interval 9 to 28 percent)
    20% (95% interval 11 to 32 percent)
    no clear change (no clear change: +4 points from Common to Strong, 95% interval −11 to +18)
    Focus Enhancement
    11% (95% interval 5 to 22 percent)
    14% (95% interval 7 to 26 percent)
    no clear change (no clear change: +4 points from Common to Strong, 95% interval −9 to +16)
    Creativity Enhancement
    7% (95% interval 3 to 17 percent)
    5% (95% interval 2 to 15 percent)
    no clear change (no clear change: −2 points from Common to Strong, 95% interval −12 to +8)

    Dosage Distribution

    Dose distribution from experience reports, one dose per report (the first listed). Doses above Q3 + 3×IQR, far above what people typically take, are left out of the median and range and listed under each route: most are real heavy doses or overdoses, not mistakes.

    Oral

    Median: 20.0 mg IQR: 15.0–20.0 mg n=271

    15 reports gave a dose above the typical range (45–250 mg), so they are not in the figures above. 5 of them mention hospital, emergency services or an overdose. Listing a dose here does not mean it is safe.

    Show the reports
    • 250 mg · mentions hospital, emergency services or an overdose
    • 120 mg · another drug taken too · mentions hospital, emergency services or an overdose
    • 100 mg
    • 100 mg
    • 100 mg
    • 90 mg · another drug taken too
    • 80 mg · another drug taken too · mentions hospital, emergency services or an overdose
    • 75 mg
    • 70 mg · another drug taken too
    • 60 mg · another drug taken too
    • 55 mg · another drug taken too · mentions hospital, emergency services or an overdose
    • 55 mg · another drug taken too
    • 50 mg · another drug taken too
    • 50 mg · another drug taken too · mentions hospital, emergency services or an overdose
    • 45 mg · another drug taken too

    Insufflated

    Median: 17.5 mg IQR: 9.4–25.0 mg n=20

    Real-World Dose Distribution

    Erowid

    From 541 of 591 recorded dose entries: those that state a weight (mg, g or µg), in routes with at least five of them. Values above Q3 + 3×IQR, far above what people typically take, are left out; they can include real heavy doses and overdoses, not only mistakes.

    Oral (n=466)

    Median: 20.0mg 25th: 15.0mg 75th: 20.0mg 90th: 25.0mg

    Insufflated (n=42)

    Median: 12.0mg 25th: 5.0mg 75th: 20.0mg 90th: 29.5mg

    Smoked (n=9)

    Median: 6.0mg 25th: 4.0mg 75th: 10.0mg 90th: 21.0mg

    Common Combinations

    Most co-occurring substances, as a share of all 508 reports filed under 2C-I; whiskers are 95% intervals

    Form / Preparation

    Most common forms and preparations, as a share of the 355 reports that give one; whiskers are 95% intervals

    Body-Weight Dosing

    Dose per kg of body weight, one dose per report (the first listed), from reports giving a weight of 30–250 kg. Doses above Q3 + 3×IQR, far above what people typically take, are left out of the median and range and listed under each route.

    Oral

    Median: 0.251 mg/kg IQR: 0.212–0.304 mg/kg n=259

    18 reports gave a dose above the typical range (0.63–3.571 mg/kg), so they are not in the figures above. 5 of them mention hospital, emergency services or an overdose. Listing a dose here does not mean it is safe.

    Show the reports

    Insufflated

    Median: 0.238 mg/kg IQR: 0.121–0.339 mg/kg n=19

    Smoked

    Median: 0.088 mg/kg IQR: 0.053–0.13 mg/kg n=5

    Unknown

    Median: 0.254 mg/kg IQR: 0.228–0.259 mg/kg n=9

    1 report gave a dose above the typical range (0.551 mg/kg), so it is not in the figures above. Listing a dose here does not mean it is safe.

    Show the report

    Redose Patterns

    Redosing behavior across 377 reports

    13.8% (95% interval 11 to 18 percent) Redosed
    1.2 Avg Doses
    60m Median Interval

    Legal Status

    EU Council Decision 2003/847/JHA (December 2003) - Binding order compelling all member states to control 2C-I within three months
    Country Status Notes
    Australia Schedule 9 Prohibited substance under the Poisons Standard. The National Drugs and Poisons Schedule Committee formally added 2C-I to Schedule 9 (the most restrictive category) in 2005.
    Austria Illegal (SMG) Controlled under the Suchtmittelgesetz (Narcotics Act). Possession, production, and sale are prohibited.
    Belgium Illegal Added to the list of illegal psychotropic substances on November 8, 2004.
    Brazil Illegal Possession, production, and sale prohibited under Portaria SVS/MS nº 344. Controlled as of February 18, 2014.
    Canada Schedule III (CDSA) Controlled under the Controlled Drugs and Substances Act as of October 31, 2016.
    China Category I Psychotropic Substance Illegal to sell, buy, import, export, and manufacture as of September 2010.
    Czech Republic Controlled Added to controlled substance lists in early 2011 alongside BZP, synthetic cannabinoids, and various cathinone derivatives.
    Denmark Controlled Classified as a controlled substance since May 2002.
    Estonia Schedule I Added to Schedule I in February 2011 alongside various synthetic cathinones and cannabinoids.
    Finland Illegal Scheduled under the government decree on substances, preparations, and plants considered to be narcotic drugs.
    France Controlled Added to the list of controlled substances in August 2004 as a synthetic analogue of mescaline.
    Germany Anlage I BtMG Controlled under Anlage I of the Betäubungsmittelgesetz (Narcotics Act) as of October 10, 1999. Manufacturing, possession, import, export, purchase, sale, procurement, and dispensing without license are prohibited.
    Greece Controlled Illegal to possess under Table A of Law 1729/87.
    Ireland Schedule 1 Controlled as a Schedule 1 substance, prohibiting possession and distribution.
    Israel Controlled Added to the list of controlled substances in December 2007, making purchase, sale, and possession illegal.
    Italy Tabella I Added to Tabella 1 (list of prohibited plants and substances) by Ministry of Health statement on January 11, 2005.
    Japan Designated Substance (Shitei-Yakubutsu) Controlled under the Pharmaceutical Affairs Law, making possession and sale illegal.
    Latvia Schedule I Classified as a Schedule I controlled substance.
    Netherlands Controlled Classified as a controlled substance under national drug legislation.
    New Zealand Schedule 3 / Class C Controlled under the catch-all analogues provision in Schedule 3 / Class C of national drug laws.
    Poland Controlled Classified as a controlled substance under national drug legislation.
    Portugal Controlled Legislation enacted in January 2005 to control 2C-I alongside 2C-T-2, 2C-T-7, and TMA-2.
    Sweden Schedule I (Narcotic) Added to Schedule I by Sveriges riksdag on March 16, 2004, published in Medical Products Agency regulation LVFS 2004:3. Classified as a substance normally without medical use.
    Switzerland Controlled (Verzeichnis D) Listed in Anhang D of the Betäubungsmittelverzeichnisverordnung (DetMV) since December 12, 1996. Possession is illegal.
    Turkey Illegal Classified as a drug. Possession, production, supply, and import are prohibited.
    United Kingdom Class A Controlled under the Misuse of Drugs Act 1971 via the phenethylamine catch-all clause. Class A carries the most severe penalties for possession and supply.
    United States Schedule I Controlled under the Synthetic Drug Abuse Prevention Act of 2012, effective July 9, 2012. Possession, distribution, and manufacture are federal offenses. Several states including Minnesota, Oklahoma, and Wisconsin had scheduled the substance prior to federal action.

    Harm Reduction

    drugs.wiki

    Identity and misrepresentation: 2C‑I has often been confused with or sold as 25I‑NBOMe/NBOH; NBOMe compounds are active at microgram doses, can cause local oral numbness and intense bitterness, are not reliably active when simply swallowed, and have been linked to hospitalizations and deaths—test samples and avoid blotters claimed to be “2C‑I.” Use multiple reagents and, ideally, lab testing (FTIR/GC‑MS) when possible. Redosing: EMCDDA notes 2C‑I can have a slower onset than expected, which has led some users to prematurely redose or add other drugs; wait at least 2 hours after an oral dose before considering any change. Intranasal risks: snorting 2C‑x (including 2C‑I) is frequently reported as extremely painful and more likely to cause nausea, vomiting, and a harsh stimulant edge; many experienced users avoid the route—if used, reduce dose markedly and expect severe nasal irritation. Cardiovascular strain: phenomenology and receptor data (5‑HT2A/2C and potential alpha‑1 adrenergic action) imply vasoconstriction, mild tachycardia and blood‑pressure elevation; those with cardiovascular disease, hypertension, or migraine susceptibility should avoid use and all users should minimize exertion/overheating. Serotonergic/seizure‑threshold cautions: avoid combinations with MAOIs entirely and with tramadol due to seizure and serotonin‑toxicity risks; SSRIs/SNRIs may blunt effects and complicate response. Lithium is specifically flagged as dangerous with classical serotonergic psychedelics due to seizure risk; do not combine. Set and setting: stimulation can amplify anxiety—use with a trusted sober sitter in a calm environment; avoid crowded, hot venues on first trials. Hydration and temperature: sip water periodically (not excessively) and take cool breaks if active; overheating increases risk with stimulating psychedelics. Dosing discipline: always allergy test with a very small amount (e.g., 1–3 mg oral), then titrate across separate sessions using a 0.001 g scale; never eyeball. Sleep and after‑effects: residual stimulation can impair sleep into the next day; plan recovery time and do not drive or operate machinery for at least 12–24 hours after significant effects resolve. Legal and substitution risk: 2C‑I is Schedule I in the U.S. and controlled in many countries; the market has historically included mislabeling (including NBOMe and DOx) so reagent test each sample.

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